diff --git a/devel/py-numba/Makefile b/devel/py-numba/Makefile
index 96ab2037fe2a..4e102975adb8 100644
--- a/devel/py-numba/Makefile
+++ b/devel/py-numba/Makefile
@@ -1,40 +1,39 @@
 PORTNAME=	numba
-DISTVERSION=	0.65.0
-PORTREVISION=	1
+DISTVERSION=	0.66.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	makc@FreeBSD.org
 COMMENT=	Optimizing compiler for Python using LLVM
 WWW=		https://numba.pydata.org/
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 .if !exists(/usr/include/omp.h)
 BROKEN=		requires OpenMP support that is missing on this architecture
 .endif
 
 # numpy version is checked at runtime
 # https://github.com/numba/numba/blob/main/numba/__init__.py#L13
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.22<2.5,1:math/py-numpy@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=2.0,1<2.5,1:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libtbb.so:devel/onetbb
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}llvmlite>=0.46.0:devel/py-llvmlite@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=1.22<2.5,1:math/py-numpy@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}llvmlite>=0.48.0:devel/py-llvmlite@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}numpy>=2.0,1<2.5,1:math/py-numpy@${PY_FLAVOR} \
 
 USES=		compiler:c++11-lang python fortran localbase
 USE_PYTHON=	pep517 concurrent autoplist unittest
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/numba/tests
 
 post-install:
 	@${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name "*.so" | ${XARGS} ${STRIP_CMD}
 
 do-test: # tests run for a very long time
 	@cd ${TEST_WRKSRC} && ${SETENV} ${TEST_ENV} ${PYTHON_CMD} -m numba.runtests
 
 .include <bsd.port.mk>
diff --git a/devel/py-numba/distinfo b/devel/py-numba/distinfo
index cd33e37651b9..007e9e71cca1 100644
--- a/devel/py-numba/distinfo
+++ b/devel/py-numba/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1775335029
-SHA256 (numba-0.65.0.tar.gz) = edad0d9f6682e93624c00125a471ae4df186175d71fd604c983c377cdc03e68b
-SIZE (numba-0.65.0.tar.gz) = 2764131
+TIMESTAMP = 1783449060
+SHA256 (numba-0.66.0.tar.gz) = b900e63a0e26c05ea9a6d5a3a5a0a177cb64c5011887bf43edb8c3ed2c38d363
+SIZE (numba-0.66.0.tar.gz) = 2806181
diff --git a/devel/py-numba/files/patch-setup.py b/devel/py-numba/files/patch-setup.py
deleted file mode 100644
index d8caccbe9433..000000000000
--- a/devel/py-numba/files/patch-setup.py
+++ /dev/null
@@ -1,11 +0,0 @@
---- setup.py.orig	2025-12-09 23:42:43 UTC
-+++ setup.py
-@@ -21,7 +21,7 @@ max_python_version = "3.15"  # exclusive
- 
- min_python_version = "3.10"
- max_python_version = "3.15"  # exclusive
--min_numpy_build_version = "2.0.0rc1"
-+min_numpy_build_version = "1.22"
- min_numpy_run_version = "1.22"
- max_numpy_run_version = "2.5"
- min_llvmlite_version = "0.46.0dev0"