diff --git a/misc/py-napari/Makefile b/misc/py-napari/Makefile
index 9badf0518583..50dc38153298 100644
--- a/misc/py-napari/Makefile
+++ b/misc/py-napari/Makefile
@@ -1,58 +1,58 @@
 PORTNAME=	napari
-DISTVERSION=	0.6.4
+DISTVERSION=	0.6.6
 CATEGORIES=	misc python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	n-dimensional array viewer in Python
 WWW=		https://napari.org/stable/ \
 		https://github.com/napari/napari
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pillow>=9.0:graphics/py-pillow@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PyOpenGL>=3.1.5:graphics/py-PyOpenGL@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}app-model>=0.4.0:devel/py-app-model@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}appdirs>=1.4.4:devel/py-appdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}cachey>=0.2.1:devel/py-cachey@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}certifi>=2018.1.18:security/py-certifi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}dask>=2021.10.0:devel/py-dask@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}imageio>=2.20:graphics/py-imageio@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>=3.2.0:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}lazy_loader>=0.3:devel/py-lazy_loader@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}magicgui>=0.7.0:x11-toolkits/py-magicgui@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}napari-console>=0.1.1:graphics/py-napari-console@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}napari-console>=0.1.4:graphics/py-napari-console@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}napari-plugin-engine>=0.1.9:graphics/py-napari-plugin-engine@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}napari-svg>=0.1.8:misc/py-napari-svg@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}npe2>=0.7.9:misc/py-npe2@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy>=1.24.2:math/py-numpy@${PY_FLAVOR} \
+		${PYNUMPY} \
 		${PYTHON_PKGNAMEPREFIX}numpydoc>=1.0.0:textproc/py-numpydoc@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pandas>=1.3.3:math/py-pandas@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pint>=0.17:devel/py-pint@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>=5.9.0:sysutils/py-psutil@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}psygnal>=0.10.0:devel/py-psygnal@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}psygnal>=0.14.2:devel/py-psygnal@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pydantic2>=2.2.0:devel/py-pydantic2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pygments>=2.6.0:textproc/py-pygments@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyyaml>0:devel/py-pyyaml@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}qtpy>=2.3.1:devel/py-QtPy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}QtPy>=2.3.1:devel/py-QtPy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scikit-image>=0.19.1:graphics/py-scikit-image@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.10.1:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}superqt>=0.7.4:x11-toolkits/py-superqt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tifffile>=2022.7.28:graphics/py-tifffile@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}toolz>=0.11.0:devel/py-toolz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=4.56.0:misc/py-tqdm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.12:devel/py-typing-extensions@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}vispy>=0.15.2:graphics/py-vispy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>=1.13.3:devel/py-wrapt@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	pep517 autoplist concurrent
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/misc/py-napari/distinfo b/misc/py-napari/distinfo
index 5e4339e22eb9..da49f131b610 100644
--- a/misc/py-napari/distinfo
+++ b/misc/py-napari/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1758415925
-SHA256 (napari-0.6.4.tar.gz) = 0a768f66447c7d5ee79a29f43f42bd054c35bbca6310d91c604aadeedf2ea5be
-SIZE (napari-0.6.4.tar.gz) = 3222013
+TIMESTAMP = 1763480985
+SHA256 (napari-0.6.6.tar.gz) = 8e1adfc737c55c2a619689fad8d9e4d115582e56f09096cf771816b0ec75c3a7
+SIZE (napari-0.6.6.tar.gz) = 3251386
diff --git a/misc/py-napari/files/patch-pyproject.toml b/misc/py-napari/files/patch-pyproject.toml
index 0da379959eab..9b256bc26efe 100644
--- a/misc/py-napari/files/patch-pyproject.toml
+++ b/misc/py-napari/files/patch-pyproject.toml
@@ -1,10 +1,21 @@
---- pyproject.toml.orig	2025-10-03 09:18:59 UTC
+--- pyproject.toml.orig	2025-10-16 09:24:27 UTC
 +++ pyproject.toml
 @@ -1,6 +1,6 @@ requires = [
  [build-system]
  requires = [
--  "setuptools >= 69",
+-  "setuptools >= 77.0.1",
 +  "setuptools",
    "setuptools_scm[toml]>=8"
  ]
  build-backend = "setuptools.build_meta"
+@@ -35,10 +35,6 @@ requires-python = ">=3.10"
+     "Operating System :: MacOS",
+ ]
+ requires-python = ">=3.10"
+-license = "BSD-3-Clause"
+-license-files = [
+-    "LICENSE",
+-]
+ dependencies = [
+     "appdirs>=1.4.4",
+     "app-model>=0.4.0,<0.5.0",