diff --git a/www/py-quilt3/Makefile b/www/py-quilt3/Makefile
index c16afc8f991a..6c05c61491e0 100644
--- a/www/py-quilt3/Makefile
+++ b/www/py-quilt3/Makefile
@@ -1,36 +1,41 @@
 PORTNAME=	quilt3
-PORTVERSION=	5.2.1
+PORTVERSION=	5.3.0
 CATEGORIES=	www python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python client for Quilt data hub
 WWW=		https://github.com/quiltdata/quilt
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}aws-requests-auth>=0.4.2:devel/py-aws-requests-auth@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}boto3>=1.10.0:www/py-boto3@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonlines>=1.2.0:devel/py-jsonlines@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>=3<5:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}platformdirs>=2:devel/py-platformdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}yaml>=5.1:devel/py-yaml@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>=2.12.4:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests-futures>=1.0.0:www/py-requests-futures@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tenacity>=5.1.1:devel/py-tenacity@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=4.32:misc/py-tqdm@${PY_FLAVOR}
 
 USES=		python:3.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
 
+OPTIONS_DEFINE=	ANNDATA
+ANNDATA_DESC=	Annotated data support
+
+ANNDATA_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}anndata>=0.8.0:devel/py-anndata@${PY_FLAVOR}
+
 .include <bsd.port.pre.mk>
 
 .if ${PYTHON_REL} < 30800
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}importlib-metadata>=0:devel/py-importlib-metadata@${PY_FLAVOR}
 .endif
 
 .include <bsd.port.post.mk>
diff --git a/www/py-quilt3/distinfo b/www/py-quilt3/distinfo
index 72c62e3a568f..3dc7a3ed5d71 100644
--- a/www/py-quilt3/distinfo
+++ b/www/py-quilt3/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1681052974
-SHA256 (quilt3-5.2.1.tar.gz) = bd64e5fc74541a7d4c3d9ad5e88f329c910e8c049c299dedfbe9c69f85e9f75d
-SIZE (quilt3-5.2.1.tar.gz) = 83890
+TIMESTAMP = 1681052998
+SHA256 (quilt3-5.3.0.tar.gz) = b75edef92b269b0a468c27c9d9bf9b0557832da7a176814c3d758087c82943bd
+SIZE (quilt3-5.3.0.tar.gz) = 84892