diff --git a/science/rdkit/Makefile b/science/rdkit/Makefile
index 040377eb09d9..3f757389dbb3 100644
--- a/science/rdkit/Makefile
+++ b/science/rdkit/Makefile
@@ -1,80 +1,79 @@
 PORTNAME=	rdkit
 DISTVERSIONPREFIX=	Release_
-DISTVERSION=	2022_03_2
-PORTREVISION=	1
+DISTVERSION=	2022_03_3
 CATEGORIES=	science
 MASTER_SITES=	https://fonts.google.com/download?family=Comic%20Neue&dummy=/:font
 DISTFILES=	Comic_Neue.zip:font
 DIST_SUBDIR=	${PORTNAME}-${PORTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Collection of cheminformatics and machine-learning software
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/license.txt
 
 BROKEN_i386=	non-constant-expression cannot be narrowed from type 'unsigned int' to 'npy_intp', see https://github.com/rdkit/rdkit/issues/4934
 
 BUILD_DEPENDS=	catch>0:devel/catch \
 		flex:textproc/flex \
 		rapidjson>=0:devel/rapidjson
 LIB_DEPENDS=	libboost_system.so:devel/boost-libs \
 		libcoordgen.so:science/coordgenlibs \
 		libfreetype.so:print/freetype2 \
 		libmaeparser.so:science/maeparser
 
 USES=		bison:build cmake compiler:c++11-lang eigen:3 python:3.7+
 USE_GITHUB=	yes
 GH_TUPLE=	rareylab:RingDecomposerLib:v1.1.3_rdkit:RingDecomposerLib/External/RingFamilies/RingDecomposerLib
 USE_LDCONFIG=	yes
 
 CMAKE_OFF=	RDK_INSTALL_INTREE RDK_USE_FLEXBISON \
 		RDK_INSTALL_STATIC_LIBS RDK_SWIG_STATIC RDK_PGSQL_STATIC \
 		RDK_OPTIMIZE_NATIVE \
 		RDK_BUILD_CPP_TESTS
 CMAKE_ARGS=	-DCATCH_DIR=${LOCALBASE}/include/catch2
 
 DATADIR=	${PREFIX}/share/RDKit
 DOCSDIR=	${PREFIX}/share/doc/RDKit
 
 PLIST_SUB=	SHLIB_VER=${PORTVERSION}
 
 OPTIONS_DEFINE=		DOCS PGSQL PYTHON
 OPTIONS_DEFAULT=	PYTHON
 OPTIONS_SUB=		yes
 
 DOCS_CMAKE_BOOL=	FREEBSD_INSTALL_DOCS
 DOCS_CMAKE_ON=		-DFREEBSD_DOCSDIR:PATH=${DOCSDIR}
 
 PGSQL_USES=		pgsql
 PGSQL_DESC=		Build the PostgreSQL cartridge
 PGSQL_CMAKE_BOOL=	RDK_BUILD_PGSQL
 
 PYTHON_CMAKE_BOOL=	RDK_BUILD_PYTHON_WRAPPERS
 PYTHON_BUILD_DEPENDS=	${PYNUMPY}
 PYTHON_LIB_DEPENDS=	${PY_BOOST}
 PYTHON_RUN_DEPENDS=	${PYNUMPY} \
 			${PY_PILLOW} \
 			${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}reportlab>0:print/py-reportlab@${PY_FLAVOR}
 
 PORTDOCS=	*
 
 .include <bsd.port.options.mk>
 
 .if ${ARCH} == aarch64 || ${ARCH} == amd64 || ${ARCH:Marm*} || ${ARCH} == i386 || ${ARCH:Mmips*el*} || ${ARCH} == riscv
 PLIST_SUB+=	LITTLE_ENDIAN=""
 .else
 PLIST_SUB+=	LITTLE_ENDIAN="@comment "
 .endif
 
 post-extract:
 	@${MKDIR} ${WRKSRC}/External/rapidjson-1.1.0
 	@cd ${WRKSRC}/External/rapidjson-1.1.0 && ${LN} -s ${LOCALBASE}/include/rapidjson include
 	@cd ${WRKSRC}/Data/Fonts && unzip ${DISTDIR}/${DIST_SUBDIR}/Comic_Neue.zip
 
 post-stage: # https://github.com/rdkit/rdkit/issues/2094
 	#@${MKDIR} ${STAGEDIR}${PREFIX}/lib/cmake
 	#@${MV} ${STAGEDIR}${PREFIX}/lib/*.cmake ${STAGEDIR}${PREFIX}/lib/cmake
 
 .include <bsd.port.mk>
diff --git a/science/rdkit/distinfo b/science/rdkit/distinfo
index ce12eb8d7743..5280e6cec246 100644
--- a/science/rdkit/distinfo
+++ b/science/rdkit/distinfo
@@ -1,7 +1,7 @@
-TIMESTAMP = 1650915023
-SHA256 (rdkit-2022.03.2/Comic_Neue.zip) = b90d32da89882e5eea971682a83efa0feac9e5d9db1e43070c9eea7a87f96ff5
-SIZE (rdkit-2022.03.2/Comic_Neue.zip) = 180686
-SHA256 (rdkit-2022.03.2/rdkit-rdkit-Release_2022_03_2_GH0.tar.gz) = e06ac1ea39a3200d27aef4d77745bba27fadfcac22bb115ffa204707487e9ae1
-SIZE (rdkit-2022.03.2/rdkit-rdkit-Release_2022_03_2_GH0.tar.gz) = 78559576
-SHA256 (rdkit-2022.03.2/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 944b5816712a48bbf88aa25d4300ce11871ddf6e971218eac08f90ed2192f715
-SIZE (rdkit-2022.03.2/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 137931
+TIMESTAMP = 1654233700
+SHA256 (rdkit-2022.03.3/Comic_Neue.zip) = b90d32da89882e5eea971682a83efa0feac9e5d9db1e43070c9eea7a87f96ff5
+SIZE (rdkit-2022.03.3/Comic_Neue.zip) = 180686
+SHA256 (rdkit-2022.03.3/rdkit-rdkit-Release_2022_03_3_GH0.tar.gz) = e2832077e258bfe906c9c0dc1664d2ba4fc0acf98bfe073c6383cb1d051b6ef0
+SIZE (rdkit-2022.03.3/rdkit-rdkit-Release_2022_03_3_GH0.tar.gz) = 78568710
+SHA256 (rdkit-2022.03.3/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 944b5816712a48bbf88aa25d4300ce11871ddf6e971218eac08f90ed2192f715
+SIZE (rdkit-2022.03.3/rareylab-RingDecomposerLib-v1.1.3_rdkit_GH0.tar.gz) = 137931