diff --git a/graphics/py-tifffile/Makefile b/graphics/py-tifffile/Makefile
index fe4322ecab13..069eeddddc4d 100644
--- a/graphics/py-tifffile/Makefile
+++ b/graphics/py-tifffile/Makefile
@@ -1,39 +1,38 @@
 PORTNAME=	tifffile
-PORTVERSION=	2026.3.3
-PORTREVISION=	1
+PORTVERSION=	2026.6.1
 CATEGORIES=	graphics python
 MASTER_SITES=	PYPI \
 		https://github.com/cgohlke/tifffile/releases/download/v${PORTVERSION}/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Read and write TIFF(r) files
-WWW=		https://github.com/cgohlke/tifffile
+WWW=		https://www.cgohlke.com/docs/tifffile/ \
+		https://github.com/cgohlke/tifffile
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=2.1,1:math/py-numpy@${PY_FLAVOR}
 
-USES=		dos2unix python:3.11+
+USES=		dos2unix python:3.12+
 USE_PYTHON=	autoplist concurrent pep517
 
 NO_ARCH=	yes
 
 OPTIONS_DEFINE=	CODECS PLOT XML # ZARR
 CODECS_DESC=	Codec for compression and predictor schemes
 PLOT_DESC=	Plotting support
 XML_DESC=	Validate and print XML
 ZARR_DESC=	Access zarr store
 
-CODECS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}imagecodecs>=2025.11.11:graphics/py-imagecodecs@${PY_FLAVOR}
+CODECS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}imagecodecs>=2026.5.10:graphics/py-imagecodecs@${PY_FLAVOR}
 PLOT_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}matplotlib>=0:math/py-matplotlib@${PY_FLAVOR}
-XML_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}defusedxml>=0:devel/py-defusedxml@${PY_FLAVOR} \
-			${PYTHON_PKGNAMEPREFIX}lxml>=0:devel/py-lxml@${PY_FLAVOR}
+XML_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}lxml>=0:devel/py-lxml@${PY_FLAVOR}
 ZARR_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}fsspec>=0:filesystems/py-fsspec@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}kerchunk>=0:filesystems/py-kerchunk@${PY_FLAVOR} \
-			${PYTHON_PKGNAMEPREFIX}zarr>=3.1.5:devel/py-zarr@${PY_FLAVOR}
+			${PYTHON_PKGNAMEPREFIX}zarr>=3.2.0:devel/py-zarr@${PY_FLAVOR}
 
 .include <bsd.port.mk>
diff --git a/graphics/py-tifffile/distinfo b/graphics/py-tifffile/distinfo
index 379e145738f6..23ba427e3c18 100644
--- a/graphics/py-tifffile/distinfo
+++ b/graphics/py-tifffile/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1775587506
-SHA256 (tifffile-2026.3.3.tar.gz) = d9a1266bed6f2ee1dd0abde2018a38b4f8b2935cb843df381d70ac4eac5458b7
-SIZE (tifffile-2026.3.3.tar.gz) = 388745
+TIMESTAMP = 1780751960
+SHA256 (tifffile-2026.6.1.tar.gz) = 626c892c0e899d959b9438e7c0e1491dc154a7fead1f1f37a991724a50eceba9
+SIZE (tifffile-2026.6.1.tar.gz) = 429694