diff --git a/biology/spoa/Makefile b/biology/spoa/Makefile
index 6ad5d248bb8e..690c3e784a6f 100644
--- a/biology/spoa/Makefile
+++ b/biology/spoa/Makefile
@@ -1,55 +1,58 @@
 PORTNAME=	spoa
-DISTVERSION=	4.1.0
+DISTVERSION=	4.1.5
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	C++ implementation of the partial order alignment (POA) algorithm
 WWW=		https://github.com/rvaser/spoa
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BROKEN_i386=	compilation fails: error: _Float16 is not supported on this target
 
 BUILD_DEPENDS=	bioparser>0:biology/bioparser \
 		biosoup>0:biology/biosoup \
 		cereal>0:devel/cereal \
 		simde>0:devel/simde
 LIB_DEPENDS=	libcpu_features.so:devel/cpu_features
 RUN_DEPENDS=	cereal>0:devel/cereal
 TEST_DEPENDS=	googletest>0:devel/googletest
 
 USES=		cmake compiler:c++11-lang localbase:ldflags
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	rvaser
 
 CMAKE_ON=	BUILD_SHARED_LIBS \
 		spoa_build_exe \
-		spoa_optimize_for_portability \
 		spoa_build_executable \
 		spoa_use_simde \
 		spoa_use_simde_nonvec \
 		spoa_use_simde_openmp \
 		spoa_use_cereal \
 		spoa_use_simde_openmp
 CMAKE_OFF=	spoa_optimize_for_native \
 		spoa_build_tests
 
 CXXFLAGS+=	-I${LOCALBASE}/include/cpu_features
 LDFLAGS+=	-lz -lcpu_features
 
 .include <bsd.port.options.mk>
 
 .if ${ARCH} == amd64 || ${ARCH} == i386
 CMAKE_ARGS+=	-Dspoa_generate_dispatch:BOOL=ON
 .endif
 
 do-test:
 	@cd ${BUILD_WRKSRC} && \
 		${SETENV} ${CONFIGURE_ENV} ${CMAKE_BIN} ${CMAKE_ARGS} -D${PORTNAME}_build_tests:BOOL=ON ${CMAKE_SOURCE_PATH} && \
 		${SETENV} ${MAKE_ENV} ${MAKE_CMD} ${MAKE_ARGS} ${ALL_TARGET} && \
 		${BUILD_WRKSRC}/bin/${PORTNAME}_test
 
+tests as of 4.1.5:
+# [==========] 23 tests from 2 test suites ran. (671 ms total)
+# [  PASSED  ] 23 tests.
+
 .include <bsd.port.mk>
diff --git a/biology/spoa/distinfo b/biology/spoa/distinfo
index 09296c5fd3cf..7b72220d5b9a 100644
--- a/biology/spoa/distinfo
+++ b/biology/spoa/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1693289273
-SHA256 (rvaser-spoa-4.1.0_GH0.tar.gz) = 43238356f00bce2ad9698fc18b3e320024172a82182dcff24d57c5cf19e342c8
-SIZE (rvaser-spoa-4.1.0_GH0.tar.gz) = 47814
+TIMESTAMP = 1762314066
+SHA256 (rvaser-spoa-4.1.5_GH0.tar.gz) = b5d323740b01255c55725e88db2548c666a05bc83b825c19cfac10586e21e7b3
+SIZE (rvaser-spoa-4.1.5_GH0.tar.gz) = 47513
diff --git a/biology/spoa/files/patch-CMakeLists.txt b/biology/spoa/files/patch-CMakeLists.txt
new file mode 100644
index 000000000000..44119c89566a
--- /dev/null
+++ b/biology/spoa/files/patch-CMakeLists.txt
@@ -0,0 +1,16 @@
+--- CMakeLists.txt.orig	2025-11-05 03:44:04 UTC
++++ CMakeLists.txt
+@@ -32,13 +32,6 @@ option(spoa_generate_dispatch "Use SIMDe to generate x
+ option(spoa_use_simde_openmp "Use SIMDe support for OpenMP SIMD" OFF)
+ option(spoa_generate_dispatch "Use SIMDe to generate x86 dispatch" OFF)
+ 
+-if (NOT spoa_generate_dispatch)
+-  if (spoa_optimize_for_portability)
+-    set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -msse4.1")
+-  elseif (spoa_optimize_for_native)
+-    set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -march=native")
+-  endif ()
+-endif ()
+ if (spoa_use_simde OR
+     spoa_use_simde_nonvec OR
+     spoa_use_simde_openmp OR