diff --git a/biology/mmseqs2/Makefile b/biology/mmseqs2/Makefile
index 755ed6f7aaa0..2ca647d74995 100644
--- a/biology/mmseqs2/Makefile
+++ b/biology/mmseqs2/Makefile
@@ -1,47 +1,43 @@
 PORTNAME=	MMseqs2
 DISTVERSION=	13-45111
-PORTREVISION=	1
+PORTREVISION=	2
 CATEGORIES=	biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Ultra fast and sensitive sequence search and clustering suite
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 BROKEN_i386=	https://github.com/soedinglab/MMseqs2/issues/418
 
 LIB_DEPENDS=	libzstd.so:archivers/zstd
 
 USES=		cmake perl5 shebangfix
 USE_GITHUB=	yes
 USE_PERL5=	build
 
 SHEBANG_GLOB=	*.sh
 GH_ACCOUNT=	soedinglab
 
-CMAKE_ARGS+=	-DUSE_SYSTEM_ZSTD:BOOL=ON
+CMAKE_ARGS+=	-DUSE_SYSTEM_ZSTD:BOOL=ON -DDISABLE_IPS4O:BOOL=ON
 LDFLAGS+=	-lpthread
 
 PLIST_FILES=	bin/mmseqs ${DATADIR}/bash-completion.sh
 
 .include <bsd.port.pre.mk>
 
-# Hangs when built with clang and SSE or x86-64 only.  Works fine with
-# -march=native.  Upstream is investigating.  To build fully optimized,
-# non-portable binary with clang: env CFLAGS='-O2 -march=native' make
 .if ${ARCH} == "amd64" && empty(CFLAGS:M*march=native*)
-USE_GCC=	yes
 # Need at least SSE2 for decent performance.  x86-64 groups SSE2 with other
 # common features in low-end AMD64 CPUs.
 CFLAGS+=	-march=x86-64
 .endif
 
 post-patch:
 	@${REINPLACE_CMD} -e 's|MMSEQS_HOME/util|${DATADIR}|g' \
 		${WRKSRC}/src/commons/Application.cpp
 
 post-stage:
 	${MV} ${STAGEDIR}${PREFIX}/util ${STAGEDIR}${DATADIR}
 
 .include <bsd.port.post.mk>