diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index c3372506de16..f7af1f988949 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -1,46 +1,46 @@
 PORTNAME=	rpy2
-PORTVERSION=	3.5.15
+PORTVERSION=	3.5.16
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python interface to the R Programming Language
 WWW=		https://rpy2.github.io/ \
 		https://github.com/rpy2/rpy2
 
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/gpl-2.0.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.0:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>=61:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libpcre2-8.so:devel/pcre2
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.0:devel/py-cffi@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.15.1:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzlocal>=0:devel/py-tzlocal@${PY_FLAVOR}
 
 USES=		compiler:c11 fortran python readline
 USE_PYTHON=	autoplist concurrent pep517
 
 MAKE_ENV=	RPY2_CFFI_MODE=BOTH
 
 OPTIONS_DEFINE=	PANDAS
 OPTIONS_DEFAULT=PANDAS
 PANDAS_DESC=	Pandas support
 
 PANDAS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pandas>=1.3.5,1:math/py-pandas@${PY_FLAVOR}
 
 .include <bsd.port.pre.mk>
 
 .if ${PYTHON_REL} < 30900
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}backports.zoneinfo>=0:devel/py-backports.zoneinfo@${PY_FLAVOR}
 .endif
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.post.mk>
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index a5b92f74d0bb..07b3148a7d36 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1708449406
-SHA256 (rpy2-3.5.15.tar.gz) = 444fae4a84dc7f233b70eaab0aa81398ee0147c4e1ae38dd4524d779d6f25b2b
-SIZE (rpy2-3.5.15.tar.gz) = 219822
+TIMESTAMP = 1712084528
+SHA256 (rpy2-3.5.16.tar.gz) = 837e2f74583658a5c4c339761a73f9434f33ef9ced3e30c64da7562165c2801b
+SIZE (rpy2-3.5.16.tar.gz) = 220028