diff --git a/devel/py-pyopencl/Makefile b/devel/py-pyopencl/Makefile
index 190733470f44..b3c3362ed3ba 100644
--- a/devel/py-pyopencl/Makefile
+++ b/devel/py-pyopencl/Makefile
@@ -1,45 +1,33 @@
 PORTNAME=	pyopencl
-PORTVERSION=	2018.2
-PORTREVISION=	11
+PORTVERSION=	2026.1.2
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	python@FreeBSD.org
 COMMENT=	Python wrapper for OpenCL
 WWW=		https://mathema.tician.de/software/pyopencl/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${LOCALBASE}/include/CL/cl.h:devel/opencl \
-		${PYTHON_PKGNAMEPREFIX}pybind11>=0:devel/py-pybind11@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy1>=0:math/py-numpy1@${PY_FLAVOR}
-LIB_DEPENDS=	${PY_BOOST} \
-		libOpenCL.so:devel/ocl-icd
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>=1.4.0:devel/py-appdirs@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}decorator>=3.2.0:devel/py-decorator@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}mako>=0.3.6:textproc/py-mako@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpy1>=0:math/py-numpy1@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pytools>=2017.6:devel/py-pytools@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}six>=1.9.0:devel/py-six@${PY_FLAVOR}
-
-USES=		compiler:c++11-lang localbase python
-USE_PYTHON=	autoplist pep517
-
-CONFIGURE_ARGS=	BOOST_INC_DIR="${LOCALBASE}/include" \
-		BOOST_LIB_DIR="${LOCALBASE}/lib" \
-		BOOST_PYTHON_LIBNAME=${PY_BOOST_LIB} \
-		CL_INC_DIR="${LOCALBASE}/include" \
-		CL_LIB_DIR="${LOCALBASE}/lib" \
-		USE_SHIPPED_BOOST=False
-
-do-configure:
-	@cd ${WRKSRC} && ${PYTHON_CMD} configure.py ${CONFIGURE_ARGS}
+		${PYTHON_PKGNAMEPREFIX}nanobind>0:devel/py-nanobind@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}numpy>0:math/py-numpy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}scikit-build-core>=0.9.3:devel/py-scikit-build-core@${PY_FLAVOR}
+LIB_DEPENDS=	libOpenCL.so:devel/ocl-icd
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>0:math/py-numpy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}platformdirs>=2.2:devel/py-platformdirs@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pytools>=2025.1.6:devel/py-pytools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.6:devel/py-typing-extensions@${PY_FLAVOR}
+
+USES=		cmake:indirect compiler:c++17-lang gl localbase python
+USE_GL=		opengl
+USE_PYTHON=	autoplist pep517 pytest
+
+MAKE_ENV=	PYOPENCL_ENABLE_GL=ON
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR}/ -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/devel/py-pyopencl/distinfo b/devel/py-pyopencl/distinfo
index 424fea712b39..efe381792c16 100644
--- a/devel/py-pyopencl/distinfo
+++ b/devel/py-pyopencl/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1537607918
-SHA256 (pyopencl-2018.2.tar.gz) = 139aea763d5665c17047dfbfe281960d5a6de29ff504e83de43294c6fafedabe
-SIZE (pyopencl-2018.2.tar.gz) = 339401
+TIMESTAMP = 1776311174
+SHA256 (pyopencl-2026.1.2.tar.gz) = 4397dd0b4cbb8b55f3e09bf87114a2465574506b363890b805b860c348b61970
+SIZE (pyopencl-2026.1.2.tar.gz) = 445132
diff --git a/devel/py-pyopencl/files/patch-aksetup__helper.py b/devel/py-pyopencl/files/patch-aksetup__helper.py
deleted file mode 100644
index e539fd297d0c..000000000000
--- a/devel/py-pyopencl/files/patch-aksetup__helper.py
+++ /dev/null
@@ -1,11 +0,0 @@
---- aksetup_helper.py.orig	2014-05-26 05:39:30 UTC
-+++ aksetup_helper.py
-@@ -131,7 +131,7 @@ def get_config(schema=None, warn_about_n
-     return expand_options(schema.read_config())
- 
- 
--def hack_distutils(debug=False, fast_link=True, what_opt=3):
-+def hack_distutils(debug=False, fast_link=True, what_opt=None):
-     # hack distutils.sysconfig to eliminate debug flags
-     # stolen from mpi4py
- 
diff --git a/devel/py-pyopencl/files/patch-src_wrap__constants.cpp b/devel/py-pyopencl/files/patch-src_wrap__constants.cpp
deleted file mode 100644
index cb9840b66ad7..000000000000
--- a/devel/py-pyopencl/files/patch-src_wrap__constants.cpp
+++ /dev/null
@@ -1,11 +0,0 @@
---- src/wrap_constants.cpp.orig	2025-05-13 14:38:07 UTC
-+++ src/wrap_constants.cpp
-@@ -67,7 +67,7 @@ void pyopencl_expose_constants(py::module &m)
- #define DECLARE_EXC(NAME, BASE) \
-   static py::exception<pyopencl::error> CL##NAME(m, #NAME, BASE);
- 
--    DECLARE_EXC(Error, NULL);
-+    DECLARE_EXC(Error, nullptr);
-     DECLARE_EXC(MemoryError, CLError.ptr());
-     DECLARE_EXC(LogicError, CLError.ptr());
-     DECLARE_EXC(RuntimeError, CLError.ptr());