diff --git a/devel/py-grpcio/Makefile b/devel/py-grpcio/Makefile
index e7b1fda56c53..ad2c4629c42a 100644
--- a/devel/py-grpcio/Makefile
+++ b/devel/py-grpcio/Makefile
@@ -1,34 +1,34 @@
 PORTNAME=	grpcio
-PORTVERSION=	1.76.0
+PORTVERSION=	1.78.0
 PORTREVISION=	0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	vanilla@FreeBSD.org
 COMMENT=	HTTP/2-based RPC framework
 WWW=		https://pypi.org/project/grpcio/
 
 LICENSE=	APACHE20
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}protobuf>=3:devel/py-protobuf@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}six>1:devel/py-six@${PY_FLAVOR}
 LIB_DEPENDS=	libcares.so:dns/c-ares
 
 USES=		compiler:c++11-lib localbase:ldflags python ssl
 BROKEN_SSL=	libressl
 BROKEN_SSL_REASON=	use of undeclared identifier 'X509_STORE_set_get_crl'
 USE_PYTHON=	autoplist cython distutils
 MAKE_ENV+=	GRPC_PYTHON_BUILD_SYSTEM_CARES=true \
 		GRPC_PYTHON_BUILD_SYSTEM_OPENSSL=true \
 		GRPC_PYTHON_BUILD_SYSTEM_ZLIB=true
 LDFLAGS+=	-lcares
 
 post-patch:
 	@${RM} ${WRKSRC}/src/python/grpcio/grpc/_cython/cygrpc.cpp
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/grpc/_cython/cygrpc*.so
 	${REINPLACE_CMD} -e 's|^.*so$$|${PYTHONPREFIX_SITELIBDIR}/grpc/_cython/cygrpc${PYTHON_TAG}.so|' ${_PYTHONPKGLIST}
 
 .include <bsd.port.mk>
diff --git a/devel/py-grpcio/distinfo b/devel/py-grpcio/distinfo
index 0a23c5418ad5..f8be23c8cf78 100644
--- a/devel/py-grpcio/distinfo
+++ b/devel/py-grpcio/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1761113373
-SHA256 (grpcio-1.76.0.tar.gz) = 7be78388d6da1a25c0d5ec506523db58b18be22d9c37d8d3a32c08be4987bd73
-SIZE (grpcio-1.76.0.tar.gz) = 12785182
+TIMESTAMP = 1771144862
+SHA256 (grpcio-1.78.0.tar.gz) = 7382b95189546f375c174f53a5fa873cef91c4b8005faa05cc5b3beea9c4f1c5
+SIZE (grpcio-1.78.0.tar.gz) = 12852416
diff --git a/devel/py-grpcio/files/patch-pyproject.toml b/devel/py-grpcio/files/patch-pyproject.toml
new file mode 100644
index 000000000000..50a7eeb6cba5
--- /dev/null
+++ b/devel/py-grpcio/files/patch-pyproject.toml
@@ -0,0 +1,11 @@
+--- pyproject.toml.orig	2026-02-03 18:17:35 UTC
++++ pyproject.toml
+@@ -23,7 +23,7 @@ name = "grpcio"
+ 
+ [project]
+ name = "grpcio"
+-license = "Apache-2.0"
++license = {text = "Apache-2.0"}
+ description = "HTTP/2-based RPC framework"
+ readme = {file = "src/python/grpcio/README.rst", content-type = "text/x-rst"}
+ authors = [{name = "The gRPC Authors", email = "grpc-io@googlegroups.com"}]
diff --git a/devel/py-grpcio/files/patch-third__party_boringssl-with-bazel_src_include_openssl_base.h b/devel/py-grpcio/files/patch-third__party_boringssl-with-bazel_src_include_openssl_base.h
index 94e724e94c7e..f0dac4877525 100644
--- a/devel/py-grpcio/files/patch-third__party_boringssl-with-bazel_src_include_openssl_base.h
+++ b/devel/py-grpcio/files/patch-third__party_boringssl-with-bazel_src_include_openssl_base.h
@@ -1,12 +1,12 @@
---- third_party/boringssl-with-bazel/src/include/openssl/base.h.orig	2023-09-06 01:32:08 UTC
+--- third_party/boringssl-with-bazel/src/include/openssl/base.h.orig	2026-02-03 18:17:40 UTC
 +++ third_party/boringssl-with-bazel/src/include/openssl/base.h
-@@ -413,9 +413,6 @@ typedef void *OPENSSL_BLOCK;
+@@ -396,9 +396,6 @@ typedef void *OPENSSL_BLOCK;
  // MSVC doesn't set __cplusplus to 201103 to indicate C++11 support (see
  // https://connect.microsoft.com/VisualStudio/feedback/details/763051/a-value-of-predefined-macro-cplusplus-is-still-199711l)
  // so MSVC is just assumed to support C++11.
 -#if !defined(BORINGSSL_NO_CXX) && __cplusplus < 201103L && !defined(_MSC_VER)
 -#define BORINGSSL_NO_CXX
 -#endif
  
  #if !defined(BORINGSSL_NO_CXX)