diff --git a/biology/libsbml/Makefile b/biology/libsbml/Makefile
index c1a72e40b190..8b7872b05dc5 100644
--- a/biology/libsbml/Makefile
+++ b/biology/libsbml/Makefile
@@ -1,80 +1,79 @@
 PORTNAME=	libsbml
-PORTVERSION=	5.20.2
+PORTVERSION=	5.20.4
 DISTVERSIONPREFIX=	v
 CATEGORIES=	biology devel
 
-PATCH_SITES=	https://github.com/sbmlteam/libsbml/commit/
-PATCHFILES=	a3e217851f18d3c5e8e2b0082fb98176738491e8.patch:-p1
-
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	API Library for Working with SBML File
 WWW=		https://sbml.org/software/libsbml/ \
 		https://synonym.caltech.edu/ \
 		https://github.com/sbmlteam/libsbml
 
 LICENSE=	LGPL21
 LICENSE_FILE=	${WRKSRC}/COPYING.txt
 
 USES=		cmake:testing iconv:build pathfix
 
 CMAKE_OFF=	EXIT_ON_ERROR \
+		LIBSBML_SKIP_SHARED_LIBRARY \
+		LIBSBML_SKIP_STATIC_LIBRARY \
 		LIBSBML_USE_STRICT_INCLUDES \
 		PYTHON_USE_API2_WARNINGS \
 		WITH_ALL_PACKAGES \
 		WITH_CHECK \
 		WITH_CPP_NAMESPACE \
 		WITH_CSHARP \
 		WITH_DOXYGEN \
 		WITH_JAVA \
 		WITH_JAVASCRIPT \
 		WITH_MATLAB \
 		WITH_OCTAVE \
 		WITH_PERL \
 		WITH_PHP \
 		WITH_R \
 		WITH_STABLE_PACKAGES \
 		WITH_WALL
 CMAKE_ON=	LIBSBML_SHARED_VERSION \
 		WITH_BZIP2 \
 		WITH_SWIG \
 		WITH_THREADSAFE_PARSER \
 		WITH_ZLIB
 CMAKE_TESTING_ON=	WITH_CHECK
 USE_CXXSTD=	c++98
 USE_LDCONFIG=	yes
 
 PLIST_SUB=	PORTVERSION=${PORTVERSION}
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	sbmlteam
 
 OPTIONS_DEFINE=	EXAMPLES PYTHON RUBY
 OPTIONS_SINGLE=	XML
 OPTIONS_SINGLE_XML=	EXPAT LIBXML2 XERCES
 OPTIONS_DEFAULT=LIBXML2 PYTHON
 OPTIONS_SUB=	yes
 
 EXAMPLES_CMAKE_BOOL=	WITH_EXAMPLES
 EXPAT_CMAKE_BOOL=	WITH_EXPAT
 EXPAT_LIB_DEPENDS=	libexpat.so:textproc/expat2
 LIBXML2_CMAKE_BOOL=	WITH_LIBXML
 LIBXML2_USE=		GNOME=libxml2
 LIBXML2_USES=		gnome
 PYTHON_BUILD_DEPENDS=	swig:devel/swig
 PYTHON_CMAKE_BOOL=	WITH_PYTHON
 PYTHON_USES=		python
 PYTHON_CMAKE_ON=	WITH_SWIG
 RUBY_BUILD_DEPENDS=	swig:devel/swig
 RUBY_CMAKE_BOOL=	WITH_RUBY
 RUBY_USES=		ruby
 XERCES_CMAKE_BOOL=	WITH_XERCES
 XERCES_LIB_DEPENDS=	libxerces-c.so:textproc/xerces-c3
 
 post-patch:
 	@${REINPLACE_CMD} -e 's|/usr/local|${LOCALBASE}|g' ${WRKSRC}/CMakeLists.txt
 
 post-install-EXAMPLES-on:
 	${MV} ${STAGEDIR}${DATADIR}/examples ${STAGEDIR}${EXAMPLESDIR}
 	${RMDIR} ${STAGEDIR}${DATADIR}
 
 .include <bsd.port.mk>
diff --git a/biology/libsbml/distinfo b/biology/libsbml/distinfo
index d8028ac58b54..7884ce4f4a5c 100644
--- a/biology/libsbml/distinfo
+++ b/biology/libsbml/distinfo
@@ -1,5 +1,3 @@
-TIMESTAMP = 1718430517
-SHA256 (sbmlteam-libsbml-v5.20.2_GH0.tar.gz) = a196cab964b0b41164d4118ef20523696510bbfd264a029df00091305a1af540
-SIZE (sbmlteam-libsbml-v5.20.2_GH0.tar.gz) = 28799745
-SHA256 (a3e217851f18d3c5e8e2b0082fb98176738491e8.patch) = ba4a19fdce1fae693d75f815c3cae52eebfaa7b0d184105b0bac1b0c14782049
-SIZE (a3e217851f18d3c5e8e2b0082fb98176738491e8.patch) = 1072
+TIMESTAMP = 1725559551
+SHA256 (sbmlteam-libsbml-v5.20.4_GH0.tar.gz) = 02c225d3513e1f5d6e3c0168456f568e67f006eddaab82f09b4bdf0d53d2050e
+SIZE (sbmlteam-libsbml-v5.20.4_GH0.tar.gz) = 28796139