diff --git a/biology/rampler/Makefile b/biology/rampler/Makefile
index ea120e8b7a51..a1a186a50173 100644
--- a/biology/rampler/Makefile
+++ b/biology/rampler/Makefile
@@ -1,26 +1,25 @@
 PORTNAME=	rampler
-DISTVERSION=	2.0.0
-PORTREVISION=	1
+DISTVERSION=	2.1.1
 CATEGORIES=	biology
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Standalone module for sampling genomic sequences
 WWW=		https://github.com/rvaser/rampler
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	bioparser>0:biology/bioparser \
 		${LOCALBASE}/include/biosoup/nucleic_acid.hpp:biology/biosoup
 
 USES=		cmake compiler:c++11-lang localbase
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	rvaser
 
 LDFLAGS+=	-lz
 
 PLIST_FILES=	bin/${PORTNAME}
 
 .include <bsd.port.mk>
diff --git a/biology/rampler/distinfo b/biology/rampler/distinfo
index dea3e8e59aea..4aa1de2305ce 100644
--- a/biology/rampler/distinfo
+++ b/biology/rampler/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1611049494
-SHA256 (rvaser-rampler-2.0.0_GH0.tar.gz) = 3a589b1ce1c2a0ac55a105cdd185b5698b4a5f6c9e015e59edee56fd64261eb8
-SIZE (rvaser-rampler-2.0.0_GH0.tar.gz) = 5190
+TIMESTAMP = 1789780944
+SHA256 (rvaser-rampler-2.1.1_GH0.tar.gz) = 9f6bd2a461e87a1f6eaa9bfd8a287da187718af5f892d05fd4cf6dd13c33fd45
+SIZE (rvaser-rampler-2.1.1_GH0.tar.gz) = 5365
diff --git a/biology/rampler/files/patch-CMakeLists.txt b/biology/rampler/files/patch-CMakeLists.txt
index cfe132f8805e..a0f874b6c053 100644
--- a/biology/rampler/files/patch-CMakeLists.txt
+++ b/biology/rampler/files/patch-CMakeLists.txt
@@ -1,31 +1,20 @@
---- CMakeLists.txt.orig	2021-01-19 09:45:19 UTC
+--- CMakeLists.txt.orig	2026-09-19 01:26:29 UTC
 +++ CMakeLists.txt
-@@ -13,19 +13,20 @@ set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${PROJECT_BINARY_DI
- set(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${PROJECT_BINARY_DIR}/lib)
- set(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${PROJECT_BINARY_DIR}/bin)
+@@ -16,7 +16,7 @@ include(GNUInstallDirs)
+ include(FetchContent)
+ include(GNUInstallDirs)
  
--if (NOT TARGET bioparser)
--  add_subdirectory(vendor/bioparser EXCLUDE_FROM_ALL)
--endif ()
--if (NOT TARGET biosoup)
--  add_subdirectory(vendor/bioparser/vendor/biosoup EXCLUDE_FROM_ALL)
--endif ()
-+#if (NOT TARGET bioparser)
-+#  add_subdirectory(vendor/bioparser EXCLUDE_FROM_ALL)
-+#endif ()
-+#if (NOT TARGET biosoup)
-+#  add_subdirectory(vendor/bioparser/vendor/biosoup EXCLUDE_FROM_ALL)
-+#endif ()
- 
- add_executable(${PROJECT_NAME}
-   src/main.cpp
-   src/sampler.cpp)
- target_link_libraries(${PROJECT_NAME}
--  bioparser
--  biosoup)
-+  #bioparser
-+  #biosoup
-+)
- target_compile_definitions(${PROJECT_NAME} PRIVATE
-   RAMPLER_VERSION="v${PROJECT_VERSION}")
+-find_package(bioparser 3.0.15 QUIET)
++find_package(bioparser REQUIRED)
+ if (NOT bioparser_FOUND)
+   FetchContent_Declare(
+     bioparser
+@@ -33,7 +33,7 @@ endif ()
+   endif ()
+ endif ()
  
+-find_package(biosoup 0.10.0 QUIET)
++find_package(biosoup REQUIRED)
+ if (NOT biosoup_FOUND)
+   FetchContent_Declare(
+     biosoup