diff --git a/math/py-pyreadr/Makefile b/math/py-pyreadr/Makefile
index 796a1c87a459..349b3df17dcc 100644
--- a/math/py-pyreadr/Makefile
+++ b/math/py-pyreadr/Makefile
@@ -1,29 +1,29 @@
 PORTNAME=	pyreadr
-PORTVERSION=	0.5.3
+PORTVERSION=	0.5.4
 CATEGORIES=	math python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Read/write R RData and Rds files into/from pandas data frames
 WWW=		https://github.com/ofajardo/pyreadr
 
 LICENSE=	AGPLv3+
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	librdata.so:math/librdata
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pandas>=1.2.0,1:math/py-pandas@${PY_FLAVOR}
 
 USES=		localbase python
-USE_PYTHON=	autoplist concurrent cython pep517
+USE_PYTHON=	autoplist concurrent cython3 pep517
 
 post-patch:
 # Clean up bundled libraries
 	@${RM} -r ${WRKSRC}/pyreadr/libs/
 	@${RM} -r ${WRKSRC}/win_libs/
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.mk>
diff --git a/math/py-pyreadr/distinfo b/math/py-pyreadr/distinfo
index 03055cb9e037..ab497ade9698 100644
--- a/math/py-pyreadr/distinfo
+++ b/math/py-pyreadr/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1742070446
-SHA256 (pyreadr-0.5.3.tar.gz) = 71517866240ed195e7933ed9c47129e738d6f23c3269556f1db4037554ecf455
-SIZE (pyreadr-0.5.3.tar.gz) = 1287391
+TIMESTAMP = 1764510982
+SHA256 (pyreadr-0.5.4.tar.gz) = 05b18cc830dceda3ef3d477bd8e50f072474e177f0cf67b6ad4fb3d7f3de11fd
+SIZE (pyreadr-0.5.4.tar.gz) = 1292809
diff --git a/math/py-pyreadr/files/patch-setup.py b/math/py-pyreadr/files/patch-setup.py
index 9d4d9a7b11c6..e0fd46217d75 100644
--- a/math/py-pyreadr/files/patch-setup.py
+++ b/math/py-pyreadr/files/patch-setup.py
@@ -1,24 +1,19 @@
---- setup.py.orig	2023-08-09 07:13:10 UTC
+--- setup.py.orig	2025-11-25 15:31:48 UTC
 +++ setup.py
-@@ -13,12 +13,7 @@ from setuptools import setup, Extension
- from Cython.Build import cythonize
- import Cython
+@@ -42,7 +42,6 @@ librdata_source_files = []
+     return False
  
--cyver = int(Cython.__version__.split(".")[0])
--if cyver < 3:
--    raise Exception("cython 3.0.0 or newer is required")
--
  librdata_source_files = []
 -librdata_source_files += glob.glob('pyreadr/libs/librdata/src/*.c')
  librdata_source_files += ['pyreadr/librdata.pyx']
  
  library_dirs = []
-@@ -54,7 +49,7 @@ elif platform.system() == 'Windows':
+@@ -78,7 +77,7 @@ elif platform.system() == 'Windows':
      libraries.append('bz2')
      libraries.append('lzma')
      
 -elif platform.system() == 'Linux':
 +elif platform.system() == 'FreeBSD':
      libraries.append('z')
      libraries.append('bz2')
      libraries.append('lzma')