diff --git a/science/py-signac/Makefile b/science/py-signac/Makefile
index 6e4f8a3e3c77..45129ee60952 100644
--- a/science/py-signac/Makefile
+++ b/science/py-signac/Makefile
@@ -1,34 +1,35 @@
 PORTNAME=	signac
 DISTVERSIONPREFIX=	v
-DISTVERSION=	2.0.0
+DISTVERSION=	2.1.0
 CATEGORIES=	science # physics
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Manage large and heterogeneous data spaces on the file system
 WWW=		https://signac.io/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}filelock>=3.0:sysutils/py-filelock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=15.0:devel/py-packaging@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}synced-collections>=1.0.0:misc/py-synced-collections@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=4.10.0:misc/py-tqdm@${PY_FLAVOR}
 PY_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}h5py>0:science/py-h5py@${PY_FLAVOR} # optional dependency
 BUILD_DEPENDS=	${PY_DEPENDS} \
 		${PYTHON_PKGNAMEPREFIX}setuptools>0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}zarr>0:devel/py-zarr@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	pep517 autoplist pytest # some tests fail because of https://github.com/zarr-developers/zarr-python/issues/1407
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	glotzerlab
 
 BINARY_ALIAS=	python=${PYTHON_CMD}
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/science/py-signac/distinfo b/science/py-signac/distinfo
index 6fd44728c072..2042cec5a257 100644
--- a/science/py-signac/distinfo
+++ b/science/py-signac/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1683183097
-SHA256 (glotzerlab-signac-v2.0.0_GH0.tar.gz) = d2a0481a9956464d8211e943cc800721abc59d5e7d66ae108132f6eab176fd38
-SIZE (glotzerlab-signac-v2.0.0_GH0.tar.gz) = 450172
+TIMESTAMP = 1689228880
+SHA256 (glotzerlab-signac-v2.1.0_GH0.tar.gz) = 4fd6096611c13487036bbff7cad6f8fcf7eaf2dac1d0ed560790a263501fe316
+SIZE (glotzerlab-signac-v2.1.0_GH0.tar.gz) = 403328