diff --git a/graphics/py-openslide-python/Makefile b/graphics/py-openslide-python/Makefile
index 4d9723146101..7ced5cef2a2b 100644
--- a/graphics/py-openslide-python/Makefile
+++ b/graphics/py-openslide-python/Makefile
@@ -1,33 +1,32 @@
 PORTNAME=	openslide-python
 DISTVERSIONPREFIX=	v
-DISTVERSION=	1.4.1
-PORTREVISION=	2
+DISTVERSION=	1.4.6
 CATEGORIES=	graphics
 #MASTER_SITES=	PYPI # no tarball
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python interface to OpenSlide library for reading virtual slide images
 WWW=		https://openslide.org \
 		https://github.com/openslide/openslide-python
 
 LICENSE=	LGPL21
 
 RUN_DEPENDS=	openslide>0:graphics/openslide \
 		${PYTHON_PKGNAMEPREFIX}pillow>0:graphics/py-pillow@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	distutils autoplist pytest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	openslide
 
 TEST_WRKSRC=	${WRKSRC}/tests
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/openslide/_convert.abi3.so
 
 # tests as of 1.4.1: 59 passed in 11.97s
 
 .include <bsd.port.mk>
diff --git a/graphics/py-openslide-python/distinfo b/graphics/py-openslide-python/distinfo
index e8a9f09caff1..7072623a982d 100644
--- a/graphics/py-openslide-python/distinfo
+++ b/graphics/py-openslide-python/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1739149442
-SHA256 (openslide-openslide-python-v1.4.1_GH0.tar.gz) = c7fe6ae42a5afa6457f8418c7c860b2dc94a0cba0f3290f361cb0f4377838576
-SIZE (openslide-openslide-python-v1.4.1_GH0.tar.gz) = 389562
+TIMESTAMP = 1780899176
+SHA256 (openslide-openslide-python-v1.4.6_GH0.tar.gz) = 19801c3ea8f71728ed91af165cee09fb4bbb889c98edb23c1514353d7cb13070
+SIZE (openslide-openslide-python-v1.4.6_GH0.tar.gz) = 437912
diff --git a/graphics/py-openslide-python/files/patch-pyproject.toml b/graphics/py-openslide-python/files/patch-pyproject.toml
new file mode 100644
index 000000000000..83bbd382aaf0
--- /dev/null
+++ b/graphics/py-openslide-python/files/patch-pyproject.toml
@@ -0,0 +1,11 @@
+--- pyproject.toml.orig	2026-06-08 06:13:21 UTC
++++ pyproject.toml
+@@ -5,8 +5,6 @@ readme = "README.md"
+ ]
+ description = "Python interface to OpenSlide"
+ readme = "README.md"
+-license = "LGPL-2.1-only AND BSD-3-Clause AND MIT AND LicenseRef-Public-Domain"
+-license-files = ["COPYING.LESSER", "**/LICENSE.*"]
+ keywords = ["OpenSlide", "whole-slide image", "virtual slide", "library"]
+ classifiers = [
+     "Development Status :: 5 - Production/Stable",