diff --git a/devel/py-cffi/Makefile b/devel/py-cffi/Makefile
index a12e6422650e..efe70971559f 100644
--- a/devel/py-cffi/Makefile
+++ b/devel/py-cffi/Makefile
@@ -1,34 +1,34 @@
 PORTNAME=	cffi
-PORTVERSION=	2.0.0
+PORTVERSION=	2.1.0
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Foreign Function Interface for Python calling C code
 WWW=		https://cffi.readthedocs.io/en/stable/ \
 		https://github.com/python-cffi/cffi
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=0:devel/py-setuptools@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=61:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>=0:devel/py-wheel@${PY_FLAVOR}
 LIB_DEPENDS=	libffi.so:devel/libffi
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pycparser>=0:devel/py-pycparser@${PY_FLAVOR}
 
 USES=		compiler:c11 localbase python
 USE_PYTHON=	autoplist concurrent cython pep517 pytest
 
 TEST_ENV=	PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 
 .include <bsd.port.pre.mk>
 
 .if ${CHOSEN_COMPILER_TYPE} == clang
 CFLAGS+=	-Wno-shift-negative-value
 .endif
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.post.mk>
diff --git a/devel/py-cffi/distinfo b/devel/py-cffi/distinfo
index d827c4782810..be76e6f587ac 100644
--- a/devel/py-cffi/distinfo
+++ b/devel/py-cffi/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1767157623
-SHA256 (cffi-2.0.0.tar.gz) = 44d1b5909021139fe36001ae048dbdde8214afa20200eda0f64c068cac5d5529
-SIZE (cffi-2.0.0.tar.gz) = 523588
+TIMESTAMP = 1783564046
+SHA256 (cffi-2.1.0.tar.gz) = efc1cdd798b1aaf39b4610bba7aad28c9bea9b910f25c784ccf9ec1fa719d1f9
+SIZE (cffi-2.1.0.tar.gz) = 531036
diff --git a/devel/py-cffi/files/patch-pyproject.toml b/devel/py-cffi/files/patch-pyproject.toml
index d764deb2b8f1..c3b2988b2a45 100644
--- a/devel/py-cffi/files/patch-pyproject.toml
+++ b/devel/py-cffi/files/patch-pyproject.toml
@@ -1,20 +1,21 @@
---- pyproject.toml.orig	2025-09-08 21:59:32 UTC
+--- pyproject.toml.orig	2026-07-06 20:52:02 UTC
 +++ pyproject.toml
-@@ -2,7 +2,7 @@ requires = [
+@@ -1,7 +1,7 @@ requires = [
+ [build-system]
  requires = [
-     # first version that supports Python 3.12; older versions may work
-     # with previous Python versions, but are not tested
--    "setuptools >= 66.1"
+     # Required for PEP 639 support
+-    "setuptools >= 77.0.3"
 +    "setuptools >= 61"
  ]
  build-backend = "setuptools.build_meta"
  
-@@ -16,7 +16,7 @@ readme = {file = "README.md", content-type = "text/mar
+@@ -15,8 +15,7 @@ readme = "README.md"
  
  description = "Foreign Function Interface for Python calling C code."
- readme = {file = "README.md", content-type = "text/markdown"}
--license = "MIT"
-+license = {text = "MIT"}
+ readme = "README.md"
+-license = "MIT-0"
+-license-files = ["LICENSE"]
++license = {text = "MIT-0"}
  classifiers = [
      "Programming Language :: Python",
      "Programming Language :: Python :: 3",