diff --git a/biology/snpeff/Makefile b/biology/snpeff/Makefile
index ac4b81e11561..a05edccb076e 100644
--- a/biology/snpeff/Makefile
+++ b/biology/snpeff/Makefile
@@ -1,43 +1,43 @@
 PORTNAME=	snpeff
-DISTVERSION=	5.0
+DISTVERSION=	5.1
 CATEGORIES=	biology java python
 MASTER_SITES=	https://snpeff.blob.core.windows.net/versions/
 DISTNAME=	snpEff_latest_core
 DIST_SUBDIR=	${PORTNAME}-${PORTVERSION}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Genetic variant annotation and effect prediction toolbox
 WWW=		http://snpeff.sourceforge.net/
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 RUN_DEPENDS=	bash:shells/bash
 
 USES=		python:3.6+ shebangfix zip
 USE_JAVA=	yes
 
 JAVA_VERSION=	17+
 SHEBANG_FILES=	scripts/* scripts/gsa/*
 
 NO_BUILD=	yes
 NO_ARCH=	yes
 WRKSRC=		${WRKDIR}/snpEff
 
 LIBEXEC_DIR=	${PREFIX}/libexec/snpeff
 
 pre-configure:
 	${REINPLACE_CMD} -e 's|%%JAVAJARDIR%%|${JAVAJARDIR}|g' \
 			 -e 's|%%JAVA_HOME%%|${JAVA_HOME}|g' \
 			 ${WRKSRC}/scripts/snpEff ${WRKSRC}/scripts/snpSift
 
 do-install:
 	${MKDIR} ${STAGEDIR}${JAVAJARDIR}/snpeff
 	${MKDIR} ${STAGEDIR}${LIBEXEC_DIR}
 	${INSTALL_SCRIPT} ${WRKSRC}/scripts/snpEff ${STAGEDIR}${PREFIX}/bin
 	${INSTALL_SCRIPT} ${WRKSRC}/scripts/snpSift ${STAGEDIR}${PREFIX}/bin
 	${INSTALL_DATA} ${WRKSRC}/*.jar ${STAGEDIR}${JAVAJARDIR}/snpeff
 	${INSTALL_DATA} ${WRKSRC}/*.config ${STAGEDIR}${JAVAJARDIR}/snpeff
 	cd ${WRKSRC}/scripts && ${COPYTREE_BIN} . ${STAGEDIR}${LIBEXEC_DIR}
 
 .include <bsd.port.mk>
diff --git a/biology/snpeff/distinfo b/biology/snpeff/distinfo
index decfc79a708d..f57ab2e7febf 100644
--- a/biology/snpeff/distinfo
+++ b/biology/snpeff/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1618847647
-SHA256 (snpeff-5.0/snpEff_latest_core.zip) = 85d907b5dd9e9008a0cf245956e3c9077a31e45f21a1b580d9b98a53fd8dcb9d
-SIZE (snpeff-5.0/snpEff_latest_core.zip) = 45828841
+TIMESTAMP = 1671473460
+SHA256 (snpeff-5.1/snpEff_latest_core.zip) = 919e0595c08e86d1dd82279723c83cb872070244ee4ce0cb3167bde2b272893b
+SIZE (snpeff-5.1/snpEff_latest_core.zip) = 67191760