diff --git a/devel/py-grpcio/Makefile b/devel/py-grpcio/Makefile
index 6ff1bd76d111..7697ca91e80e 100644
--- a/devel/py-grpcio/Makefile
+++ b/devel/py-grpcio/Makefile
@@ -1,32 +1,32 @@
 # Created by: vanilla@
 
 PORTNAME=	grpcio
-PORTVERSION=	1.46.0
+PORTVERSION=	1.46.1
 CATEGORIES=	devel python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	vanilla@FreeBSD.org
 COMMENT=	HTTP/2-based RPC framework
 
 LICENSE=	APACHE20
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}protobuf>=3:devel/py-protobuf@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}six>1:devel/py-six@${PY_FLAVOR}
 LIB_DEPENDS=	libcares.so:dns/c-ares
 
 USES=		compiler:c++11-lib localbase:ldflags python:3.6+ ssl
 USE_PYTHON=	autoplist cython distutils
 MAKE_ENV+=	GRPC_PYTHON_BUILD_SYSTEM_CARES=true \
 		GRPC_PYTHON_BUILD_SYSTEM_OPENSSL=true \
 		GRPC_PYTHON_BUILD_SYSTEM_ZLIB=true
 LDFLAGS+=	-lcares
 
 post-patch:
 	@${RM} ${WRKSRC}/src/python/grpcio/grpc/_cython/cygrpc.cpp
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/grpc/_cython/cygrpc*.so
 	${REINPLACE_CMD} -e 's|${PYTHONPREFIX_SITELIBDIR}/\(.*\)/grpcio/grpc/_cython/cygrpc${PYTHON_EXT_SUFFIX}.so|${PYTHONPREFIX_SITELIBDIR}/grpc/_cython/cygrpc${PYTHON_EXT_SUFFIX}.so|g' ${_PYTHONPKGLIST}
 
 .include <bsd.port.mk>
diff --git a/devel/py-grpcio/distinfo b/devel/py-grpcio/distinfo
index 40ed6ada87ce..c215f3cee180 100644
--- a/devel/py-grpcio/distinfo
+++ b/devel/py-grpcio/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1652842181
-SHA256 (grpcio-1.46.0.tar.gz) = ef37ff444d248ff8ea5e175a7807ce19e324831bc00d466169191cd9aad0ee36
-SIZE (grpcio-1.46.0.tar.gz) = 21845658
+TIMESTAMP = 1652999130
+SHA256 (grpcio-1.46.1.tar.gz) = 4835b0f5fedbee3a3d6eea48f4e65dffd30b52c078690fa97ddc9fcea1e3b35d
+SIZE (grpcio-1.46.1.tar.gz) = 21842101