diff --git a/biology/py-orange3-bioinformatics/Makefile b/biology/py-orange3-bioinformatics/Makefile
index 5ca207f97b00..f0bcfa101b50 100644
--- a/biology/py-orange3-bioinformatics/Makefile
+++ b/biology/py-orange3-bioinformatics/Makefile
@@ -1,28 +1,33 @@
 PORTNAME=	orange3-bioinformatics
-DISTVERSION=	3.2.2
-PORTREVISION=	3
+DISTVERSION=	4.3.1
 CATEGORIES=	biology python
+MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
+DISTNAME=	Orange3-Bioinformatics-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Orange add-on providing common functionality for bioinformatics
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 DEPRECATED=	Uses EOL Python 2.7 via misc/orange3
 EXPIRATION_DATE=2021-06-23
 
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR}
 RUN_DEPENDS=	orange3>0:misc/orange3 \
 		${PYTHON_PKGNAMEPREFIX}Genesis-PyAPI>0:biology/py-Genesis-PyAPI@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}point-annotator>=2.0:math/py-point-annotator@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pyclipper>=1.2.0:math/py-pyclipper@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests-cache>0:www/py-requests-cache@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}resdk>0:biology/py-resdk@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}scipy>=1.5.0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}serverfiles>0:misc/py-serverfiles@${PY_FLAVOR}
 
 USES=		python:3.4+
-USE_GITHUB=	yes
-GH_ACCOUNT=	biolab
 USE_PYTHON=	distutils autoplist
+
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/py-orange3-bioinformatics/distinfo b/biology/py-orange3-bioinformatics/distinfo
index 66ecb66011d0..71ee4b689827 100644
--- a/biology/py-orange3-bioinformatics/distinfo
+++ b/biology/py-orange3-bioinformatics/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1539463729
-SHA256 (biolab-orange3-bioinformatics-3.2.2_GH0.tar.gz) = 4654d77e3a4298b49f12289f1ade24cb8c8831753488c516764edef2ce472455
-SIZE (biolab-orange3-bioinformatics-3.2.2_GH0.tar.gz) = 1869440
+TIMESTAMP = 1619513096
+SHA256 (Orange3-Bioinformatics-4.3.1.tar.gz) = 4017518f9eeef0e8a9016a3e1c19b362f9f4d7f3e9dd07da0d8615a96a3b8447
+SIZE (Orange3-Bioinformatics-4.3.1.tar.gz) = 2943722