diff --git a/www/py-werkzeug/Makefile b/www/py-werkzeug/Makefile
index 9c6b8785ab96..3f4d8dc35f73 100644
--- a/www/py-werkzeug/Makefile
+++ b/www/py-werkzeug/Makefile
@@ -1,32 +1,32 @@
 PORTNAME=	werkzeug
-PORTVERSION=	2.1.2
+PORTVERSION=	2.2.1
 CATEGORIES=	www python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	Werkzeug-${DISTVERSION}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python utilities collection for building WSGI applications
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}openssl>=16.0:security/py-openssl@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}markupsafe>=2.1.1:textproc/py-markupsafe@${PY_FLAVOR}
 
 USES=		cpe python:3.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
 
 CPE_VENDOR=	palletsprojects
 
 OPTIONS_DEFINE=	EXAMPLES WATCHDOG
 WATCHDOG_DESC=	Monitor filesystem events
 
 WATCHDOG_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}watchdog>=0:devel/py-watchdog@${PY_FLAVOR}
 
 post-install-EXAMPLES-on:
 	${MKDIR} ${STAGEDIR}${EXAMPLESDIR}
 	cd ${WRKSRC}/examples/ && ${COPYTREE_SHARE} . ${STAGEDIR}${EXAMPLESDIR}
 
 .include <bsd.port.mk>
diff --git a/www/py-werkzeug/distinfo b/www/py-werkzeug/distinfo
index 72cb452b1a73..3e001c88eacd 100644
--- a/www/py-werkzeug/distinfo
+++ b/www/py-werkzeug/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1651316657
-SHA256 (Werkzeug-2.1.2.tar.gz) = 1ce08e8093ed67d638d63879fd1ba3735817f7a80de3674d293f5984f25fb6e6
-SIZE (Werkzeug-2.1.2.tar.gz) = 835169
+TIMESTAMP = 1659161211
+SHA256 (Werkzeug-2.2.1.tar.gz) = 4d7013ef96fd197d1cdeb03e066c6c5a491ccb44758a5b2b91137319383e5a5a
+SIZE (Werkzeug-2.2.1.tar.gz) = 838993