diff --git a/biology/seqan3/Makefile b/biology/seqan3/Makefile
index d731c45f36af..c4a9e6453274 100644
--- a/biology/seqan3/Makefile
+++ b/biology/seqan3/Makefile
@@ -1,28 +1,36 @@
 PORTNAME=	seqan3
 DISTVERSION=	3.0.3
 CATEGORIES=	biology devel math
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	C++ header-only library for biological sequence analysis
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 HPP_DEPENDS=	cereal>0:devel/cereal \
 		range-v3>0:devel/range-v3
 BUILD_DEPENDS=	${HPP_DEPENDS}
 RUN_DEPENDS=	${HPP_DEPENDS} \
 		coin-or-lemon>0:math/lemon
 
 USES=		cmake localbase
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	seqan
 GH_TUPLE=	xxsds:sdsl-lite:9a0d567:sdsl_lite/submodules/sdsl-lite
 
+TEST_WRKSRC=	${WRKSRC}/.test
+
 NO_ARCH=	yes
 
 post-install:
 	@${RM} -r ${STAGEDIR}${DOCSDIR}
 
+do-test: # fail: https://github.com/seqan/seqan3/issues/2643
+	@${MKDIR} ${TEST_WRKSRC} && cd ${TEST_WRKSRC} && \
+		${SETENV} ${CONFIGURE_ENV} ${CMAKE_BIN} ${CMAKE_ARGS} ${WRKSRC}/test/unit && \
+		${SETENV} ${MAKE_ENV} ${MAKE_CMD} ${MAKE_ARGS} ${ALL_TARGET} && \
+		ctest
+
 .include <bsd.port.mk>