diff --git a/science/py-MDAnalysis/Makefile b/science/py-MDAnalysis/Makefile
index 45c56890488b..81b0482018d6 100644
--- a/science/py-MDAnalysis/Makefile
+++ b/science/py-MDAnalysis/Makefile
@@ -1,41 +1,44 @@
 PORTNAME=	MDAnalysis
 DISTVERSION=	2.10.0
-PORTREVISION=	1
+PORTREVISION=	2
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 DISTNAME=	${PORTNAME:tl}-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python library to analyze molecular dynamics trajectories
 WWW=		https://www.mdanalysis.org
 
 LICENSE=	GPLv2
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.26.0:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}packaging>=2.0:devel/py-packaging@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}GridDataFormats>=0.4.0:math/py-GridDataFormats@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}biopython>=1.80:biology/py-biopython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}gsd>3.0.0:science/py-gsd@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}joblib>=0.12:devel/py-joblib@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>=1.5.1:math/py-matplotlib@${PY_FLAVOR} \
 		clustalw2:biology/clustalw \
 		rdkit>0:science/rdkit \
 		${PYTHON_PKGNAMEPREFIX}mmtf-python>=1.0.0:science/py-mmtf-python@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}networkx>=2.0:math/py-networkx@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}numpy>=1.26.0:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.5.0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}seaborn>0:math/py-seaborn@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tqdm>=4.43.0:misc/py-tqdm@${PY_FLAVOR}
 
 USES=		compiler:c++11-lang python
 USE_PYTHON=	distutils cython autoplist pytest
 
-# tests as of 2.10.0
-
 .if !defined(WITH_DEBUG)
 LDFLAGS+=	-s
 .endif
 
+TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
+
+post-patch:
+	@${RM} -r ${WRKSRC}/doc
+
 .include <bsd.port.mk>
diff --git a/science/py-MDAnalysis/files/patch-MDAnalysis_lib_formats_src_xdrfile.c b/science/py-MDAnalysis/files/patch-MDAnalysis_lib_formats_src_xdrfile.c
deleted file mode 100644
index d9dee2efbac3..000000000000
--- a/science/py-MDAnalysis/files/patch-MDAnalysis_lib_formats_src_xdrfile.c
+++ /dev/null
@@ -1,15 +0,0 @@
-- workaround for invalid C/C++ code, see https://github.com/MDAnalysis/mdanalysis/issues/4589
-
---- MDAnalysis/lib/formats/src/xdrfile.c.orig	2025-10-17 00:00:00 UTC
-+++ MDAnalysis/lib/formats/src/xdrfile.c
-@@ -132,8 +132,8 @@ struct XDR
- 		int (*x_getbytes) (XDR *__xdrs, char *__addr, unsigned int __len);
- 		int (*x_putbytes) (XDR *__xdrs, char *__addr, unsigned int __len);
- 		/* two next routines are not 64-bit IO safe - don't use! */
--		int64_t (*x_getpostn) (XDR *__xdrs);
--		int (*x_setpostn) (XDR *__xdrs, int64_t __pos, int __whence);
-+		off_t (*x_getpostn) (XDR *__xdrs);
-+		off_t (*x_setpostn) (XDR *__xdrs, off_t __pos, int __whence);
- 		void (*x_destroy) (XDR *__xdrs);
- 	}
-     *x_ops;