diff --git a/biology/hhsuite/Makefile b/biology/hhsuite/Makefile
index 7686f86e7278..60e0fcb6ad66 100644
--- a/biology/hhsuite/Makefile
+++ b/biology/hhsuite/Makefile
@@ -1,42 +1,40 @@
 PORTNAME=	hhsuite
 DISTVERSIONPREFIX=	v
 DISTVERSION=	3.3.0
 PORTREVISION=	1
 CATEGORIES=	biology science
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Remote protein homology detection suite
 WWW=		https://github.com/soedinglab/hh-suite
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BROKEN_armv7=	compilation fails: no member named 'neon_f64' in 'simde__m128d_private', see https://github.com/soedinglab/hh-suite/issues/322
-
 LIB_DEPENDS=	libmpi.so:net/openmpi
 
 USES=		compiler:c++11-lang cmake perl5 python shebangfix
 SHEBANG_GLOB=	*.pl *.py
 USE_GITHUB=	yes
 GH_ACCOUNT=	soedinglab
 GH_PROJECT=	hh-suite
 
 LDFLAGS+=	-Wl,-rpath,${LOCALBASE}/mpi/openmpi/lib -L${LOCALBASE}/mpi/openmpi/lib -lmpi # force linking to openmpi, and not to mpich
 
 .if !exists(/usr/include/omp.h)
 PLIST_SUB+=	OPENMP="@comment "
 .else
 PLIST_SUB+=	OPENMP=""
 .endif
 
 .include <bsd.port.options.mk>
 
 .if ${ARCH} == aarch64
 CMAKE_ON=	HAVE_ARM8
 .elif ${ARCH} == amd64 || ${ARCH} == i386
 CMAKE_ON=	HAVE_SSE2
 .elif ${ARCH} == powerpc64le
 CMAKE_ON=	HAVE_POWER8
 .endif
 
 .include <bsd.port.mk>
diff --git a/biology/hhsuite/files/patch-lib_simde_simde_x86_sse2.h b/biology/hhsuite/files/patch-lib_simde_simde_x86_sse2.h
new file mode 100644
index 000000000000..898d98065043
--- /dev/null
+++ b/biology/hhsuite/files/patch-lib_simde_simde_x86_sse2.h
@@ -0,0 +1,11 @@
+--- lib/simde/simde/x86/sse2.h.orig	2022-10-01 09:24:35 UTC
++++ lib/simde/simde/x86/sse2.h
+@@ -6591,7 +6591,7 @@ simde_x_mm_negate_pd(simde__m128d a) {
+ 
+     #if defined(SIMDE_POWER_ALTIVEC_P9_NATIVE)
+       r_.altivec_f64 = vec_neg(a_.altivec_f64);
+-    #elif defined(SIMDE_ARM_NEON_A32V7_NATIVE)
++    #elif defined(SIMDE_ARM_NEON_A64V8_NATIVE)
+       r_.neon_f64 = vnegq_f64(a_.neon_f64);
+     #elif defined(SIMDE_WASM_SIMD128d_NATIVE)
+       r_.wasm_v128d = wasm_f64x2_neg(a_.wasm_v128d);