diff --git a/biology/py-dnaio/Makefile b/biology/py-dnaio/Makefile
index 3f7c013b8d84..685d4e5f358c 100644
--- a/biology/py-dnaio/Makefile
+++ b/biology/py-dnaio/Makefile
@@ -1,18 +1,18 @@
 PORTNAME=	dnaio
-DISTVERSION=	0.5.0	# py-cutadapt 3.2 requires 0.5.x
+DISTVERSION=	0.5.1	# py-cutadapt 3.3 requires 0.5.x
 CATEGORIES=	biology python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Read and write FASTQ and FASTA
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>0:devel/py-setuptools_scm@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist distutils
 
 .include <bsd.port.mk>
diff --git a/biology/py-dnaio/distinfo b/biology/py-dnaio/distinfo
index a6a2879e226c..b1aa14a78220 100644
--- a/biology/py-dnaio/distinfo
+++ b/biology/py-dnaio/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1612290443
-SHA256 (dnaio-0.5.0.tar.gz) = 6d01979159057954a265d81767f8cb26721a6d3a458601a73d1647792a50134c
-SIZE (dnaio-0.5.0.tar.gz) = 126321
+TIMESTAMP = 1620087008
+SHA256 (dnaio-0.5.1.tar.gz) = c68ecffbf653dfe122f1c10fb8d7c5957ad68acc5c9035c66f81eba1a591d31c
+SIZE (dnaio-0.5.1.tar.gz) = 126820
diff --git a/biology/py-dnaio/pkg-descr b/biology/py-dnaio/pkg-descr
index f17a9a9ed741..3ded467c3308 100644
--- a/biology/py-dnaio/pkg-descr
+++ b/biology/py-dnaio/pkg-descr
@@ -1,5 +1,5 @@
-dnaio is a Python 3 library for fast parsing of FASTQ and also FASTA files. The
-code was previously part of the cutadapt tool and has been improved since it
-has been split out.
+dnaio is a Python 3 library for fast input and output of FASTQ and FASTA files.
+It supports paired-end data in separate files, interleaved paired-end in a
+single file and compression using gzip, bzip, and xz.
 
 WWW: https://pypi.python.org/pypi/dnaio