diff --git a/math/py-chaospy/Makefile b/math/py-chaospy/Makefile
index 24bd4f62c509..64f3b7f1cc8e 100644
--- a/math/py-chaospy/Makefile
+++ b/math/py-chaospy/Makefile
@@ -1,35 +1,35 @@
 PORTNAME=	chaospy
 DISTVERSIONPREFIX=	v
-DISTVERSION=	4.3.11
-PORTREVISION=	5
+DISTVERSION=	4.3.21
 CATEGORIES=	math python
 #MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Toolbox for performing uncertainty quantification
 WWW=		https://github.com/jonathf/chaospy
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PY_SETUPTOOLS} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.16:math/py-numpy@${PY_FLAVOR} \
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=1.20:math/py-numpy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}matplotlib>0:math/py-matplotlib@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}numpoly>0:math/py-numpoly@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR}
+		${PYTHON_PKGNAMEPREFIX}numpoly>=1.2.12:math/py-numpoly@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}scipy>0:science/py-scipy@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}setuptools>=40.9.0:devel/py-setuptools@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}scikit-learn>0:science/py-scikit-learn@${PY_FLAVOR}
 
 USES=		python
 USE_PYTHON=	pep517 autoplist pytest
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	jonathf
 
 NO_ARCH=	yes
 
 do-test: # tests hang: https://github.com/jonathf/chaospy/issues/406
 	@cd ${WRKSRC} && pytest --doctest-modules chaospy/
 
 .include <bsd.port.mk>
diff --git a/math/py-chaospy/distinfo b/math/py-chaospy/distinfo
index b1f302357bf8..a596c069ce61 100644
--- a/math/py-chaospy/distinfo
+++ b/math/py-chaospy/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1679988979
-SHA256 (jonathf-chaospy-v4.3.11_GH0.tar.gz) = b204442a21a0e3b9c6129009a0f7ef3ba13b9e6808cd56f9c49a1d8710fc2480
-SIZE (jonathf-chaospy-v4.3.11_GH0.tar.gz) = 2429578
+TIMESTAMP = 1780672540
+SHA256 (jonathf-chaospy-v4.3.21_GH0.tar.gz) = 59709f7854f9cd3e88bbbfbafd0cda292123f5145e6a8baff082eea85d1fecf6
+SIZE (jonathf-chaospy-v4.3.21_GH0.tar.gz) = 2429764