diff --git a/science/py-dwave-preprocessing/Makefile b/science/py-dwave-preprocessing/Makefile
index c987ad6800bb..b5073ed0fe66 100644
--- a/science/py-dwave-preprocessing/Makefile
+++ b/science/py-dwave-preprocessing/Makefile
@@ -1,38 +1,37 @@
 PORTNAME=	dwave-preprocessing
-DISTVERSION=	0.6.5
+DISTVERSION=	0.6.6
 CATEGORIES=	science python # quantum-computing
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	DWave: Preprocessing tools to aid in solving binary quadratic models
 WWW=		https://github.com/dwavesystems/dwave-preprocessing
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dimod>=0.12.14:science/py-dimod@${PY_FLAVOR} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cython3>0:lang/cython3@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}dimod>=0.12.6:science/py-dimod@${PY_FLAVOR}
+RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}dimod>=0.12.6:science/py-dimod@${PY_FLAVOR} \
 		${PYNUMPY}
-BUILD_DEPENDS=	${PY_DEPENDS} \
-		${PYTHON_PKGNAMEPREFIX}wheel>=0.30.0:devel/py-wheel@${PY_FLAVOR}
-RUN_DEPENDS=	${PY_DEPENDS}
 
 USES=		localbase:ldflags python
-USE_PYTHON=	distutils cython unittest # 1 test fails, see https://github.com/dwavesystems/dwave-preprocessing/issues/74
+USE_PYTHON=	distutils unittest # 1 test fails, see https://github.com/dwavesystems/dwave-preprocessing/issues/74
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	dwavesystems
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/tests
 
 post-install:
 	# strip binaries
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/preprocessing/cyfix_variables${PYTHON_EXT_SUFFIX}.so \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/preprocessing/presolve/cypresolve${PYTHON_EXT_SUFFIX}.so
 	# remove conflicting __init__.py, see https://github.com/dwavesystems/dwave-preprocessing/issues/45
 	@${RM} -r \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__init__.py \
 		${STAGEDIR}${PYTHON_SITELIBDIR}/dwave/__pycache__
 
 .include <bsd.port.mk>
diff --git a/science/py-dwave-preprocessing/distinfo b/science/py-dwave-preprocessing/distinfo
index c0f680d18cd2..da8873cbb9b2 100644
--- a/science/py-dwave-preprocessing/distinfo
+++ b/science/py-dwave-preprocessing/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1705614428
-SHA256 (dwavesystems-dwave-preprocessing-0.6.5_GH0.tar.gz) = c331613c23af99ad76222b805d7a4e176eb09affcf57f61f6016b6761d7acad9
-SIZE (dwavesystems-dwave-preprocessing-0.6.5_GH0.tar.gz) = 126275
+TIMESTAMP = 1721009063
+SHA256 (dwavesystems-dwave-preprocessing-0.6.6_GH0.tar.gz) = 3ffbf8694997f2527380e6080f7f6fa7501a85927ca98ace87672e9b0d251438
+SIZE (dwavesystems-dwave-preprocessing-0.6.6_GH0.tar.gz) = 126646