diff --git a/misc/snakemake/Makefile b/misc/snakemake/Makefile
index 79bc167eb845..7189fab56596 100644
--- a/misc/snakemake/Makefile
+++ b/misc/snakemake/Makefile
@@ -1,31 +1,34 @@
 PORTNAME=	snakemake
-DISTVERSION=	5.32.2
+DISTVERSION=	6.2.1
 CATEGORIES=	misc python
 MASTER_SITES=	CHEESESHOP
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Workflow management system
 
 LICENSE=	MIT
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}appdirs>0:devel/py-appdirs@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}configargparse>0:devel/py-configargparse@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}datrie>0:devel/py-datrie@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}docutils>0:textproc/py-docutils@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}filelock>0:sysutils/py-filelock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}GitPython>0:devel/py-gitpython@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}jsonschema>0:devel/py-jsonschema@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}nbformat>0:devel/py-nbformat@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}PuLP>=2.0:math/py-PuLP@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}psutil>0:sysutils/py-psutil@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}ratelimiter>0:devel/py-ratelimiter@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}smart-open>0:net/py-smart-open@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}stopit>0:devel/py-stopit@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}toposort>0:devel/py-toposort@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wrapt>0:devel/py-wrapt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}yaml>0:devel/py-yaml@${PY_FLAVOR}
 
 USES=		python:3.5+
 USE_PYTHON=	distutils noflavors autoplist
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/misc/snakemake/distinfo b/misc/snakemake/distinfo
index 800b036185c2..37bc58a42be4 100644
--- a/misc/snakemake/distinfo
+++ b/misc/snakemake/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1613275993
-SHA256 (snakemake-5.32.2.tar.gz) = ff35f3c5d283c5b38a926b943f18aa732cc8af4bd1f59471907ef3adda1b018c
-SIZE (snakemake-5.32.2.tar.gz) = 254698
+TIMESTAMP = 1619167037
+SHA256 (snakemake-6.2.1.tar.gz) = cbb7688aee07a7e9a223a3b05bc9425d6245f8ad0990fc3c623e6645b02f310c
+SIZE (snakemake-6.2.1.tar.gz) = 264035