diff --git a/science/py-mp-api/Makefile b/science/py-mp-api/Makefile
index cda39e1cd11d..0080da56d2bc 100644
--- a/science/py-mp-api/Makefile
+++ b/science/py-mp-api/Makefile
@@ -1,35 +1,49 @@
 PORTNAME=	mp-api
-DISTVERSION=	0.34.0
-PORTREVISION=	2
+DISTVERSION=	0.46.4
 CATEGORIES=	science python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
+DISTNAME=	mp_api-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	API for server for the Materials Project
 WWW=		https://materialsproject.github.io/api/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-BUILD_DEPENDS=	${PY_SETUPTOOLS} \
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=61.0:devel/py-setuptools@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}boto3>0:www/py-boto3@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}custodian>0:devel/py-custodian@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}emmet-core>=0.39.8:science/py-emmet-core@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}monty>=2022.3.12:devel/py-monty@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}mpcontribs-client>=5.0.10:science/py-mpcontribs-client@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}msgpack>0:devel/py-msgpack@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pydantic2>=1.8.2:devel/py-pydantic2@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pymatgen-analysis-alloys>=0.0.3:science/py-pymatgen-analysis-alloys@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}pymatgen>=2022.3.7:science/py-pymatgen@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}requests>=2.27.1:www/py-requests@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}typing-extensions>=4.1.1:devel/py-typing-extensions@${PY_FLAVOR}
-
-USES=		python
+		${PYTHON_PKGNAMEPREFIX}deltalake>0:databases/py-deltalake@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}emmet-core>=0.87.1:science/py-emmet-core@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}monty>=2024.12.10:devel/py-monty@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}orjson>=3.10:devel/py-orjson@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pyarrow>=20.0.0:databases/py-pyarrow@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pymatgen>2024.2.20:science/py-pymatgen@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}requests>=2.23.0:www/py-requests@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}typing-extensions>=3.7.4.1:devel/py-typing-extensions@${PY_FLAVOR}
+TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest-asyncio>0:devel/py-pytest-asyncio@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pytest-cov>0:devel/py-pytest-cov@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pytest-mock>0:devel/py-pytest-mock@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}pytest-xdist>0:devel/py-pytest-xdist@${PY_FLAVOR}
+
+USES=		python:3.11+
 USE_PYTHON=	pep517 autoplist pytest
 
 NO_ARCH=	yes
 
+# tests as of 0.46.4: disable tests that require network access to the Materials
+# Project API or an API key (test_core_fetch_tools, test_core_search_tools,
+# test_blessed_entry, test_regression_batching) and the client-initialization
+# test (test_mix_in) that fails without an API key in the clean environment.
+PYTEST_BROKEN_TESTS=	test_core_fetch_tools \
+			test_core_search_tools \
+			test_mix_in \
+			test_blessed_entry \
+			test_regression_batching
+
+# tests as of 0.46.4: 22 passed 131 skipped
+
 .include <bsd.port.mk>
diff --git a/science/py-mp-api/distinfo b/science/py-mp-api/distinfo
index 0a72b491d952..aaad6a1ccf9b 100644
--- a/science/py-mp-api/distinfo
+++ b/science/py-mp-api/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1692075749
-SHA256 (mp-api-0.34.0.tar.gz) = 64cb8cadb83352715cfba83a89e228111a5cff8257021aa25529c4e90dd9d945
-SIZE (mp-api-0.34.0.tar.gz) = 702100
+TIMESTAMP = 1785554297
+SHA256 (mp_api-0.46.4.tar.gz) = c934d0e6c95acd88a7d6e22a7c718520fbb65cb070923db34c3b90821b924c89
+SIZE (mp_api-0.46.4.tar.gz) = 162993
diff --git a/science/py-mp-api/files/patch-pyproject.toml b/science/py-mp-api/files/patch-pyproject.toml
new file mode 100644
index 000000000000..83d6ddd85842
--- /dev/null
+++ b/science/py-mp-api/files/patch-pyproject.toml
@@ -0,0 +1,13 @@
+-- Fix invalid PEP 621 license declaration.
+-- Upstream uses license = "BSD-3-Clause-LBNL" which newer setuptools rejects.
+--- pyproject.toml.orig
++++ pyproject.toml
+@@ -10,7 +10,7 @@
+ description = "API Client for the Materials Project"
+ readme = "README.md"
+ requires-python = ">=3.11"
+-license = "BSD-3-Clause-LBNL"
++license = {text = "BSD-3-Clause-LBNL"}
+ classifiers = [
+   "Programming Language :: Python :: 3",
+   "Development Status :: 4 - Beta",