diff --git a/biology/py-biopython/Makefile b/biology/py-biopython/Makefile
index 9c02066adae9..7ca215dafc49 100644
--- a/biology/py-biopython/Makefile
+++ b/biology/py-biopython/Makefile
@@ -1,32 +1,32 @@
 PORTNAME=	biopython
-DISTVERSION=	1.79
+DISTVERSION=	1.80
 CATEGORIES=	biology python
 MASTER_SITES=	http://www.biopython.org/DIST/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	mauricio@arareko.net
 COMMENT=	Collection of Python modules for bioinformatics
 WWW=		https://biopython.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
 BUILD_DEPENDS=	${PYNUMPY}
 RUN_DEPENDS=	${PYNUMPY}
 
-USES=		python:3.6+
+USES=		python:3.7+
 USE_PYTHON=	distutils autoplist
 
 OPTIONS_DEFINE=		REPORTLAB
 OPTIONS_DEFAULT=	REPORTLAB
 
 REPORTLAB_DESC=		PDF support in Bio.Graphics module
 REPORTLAB_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}reportlab>0:print/py-reportlab@${PY_FLAVOR}
 
 post-install:
 	@${STRIP_CMD} \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*.so \
 		${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/Bio/*/*/*.so \
 
 .include <bsd.port.mk>
diff --git a/biology/py-biopython/distinfo b/biology/py-biopython/distinfo
index 21513e79b748..c4c5e3fdea71 100644
--- a/biology/py-biopython/distinfo
+++ b/biology/py-biopython/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1634020529
-SHA256 (biopython-1.79.tar.gz) = edb07eac99d3b8abd7ba56ff4bedec9263f76dfc3c3f450e7d2e2bcdecf8559b
-SIZE (biopython-1.79.tar.gz) = 16738730
+TIMESTAMP = 1669897294
+SHA256 (biopython-1.80.tar.gz) = 52805e9af88767e450e2df8113b5bc59e964e2e8a7bb803a83570bdbb51c0e43
+SIZE (biopython-1.80.tar.gz) = 17924553