diff --git a/science/py-mmcif/Makefile b/science/py-mmcif/Makefile
index 376cef34ae56..219c427c0ccb 100644
--- a/science/py-mmcif/Makefile
+++ b/science/py-mmcif/Makefile
@@ -1,27 +1,27 @@
 PORTNAME=	mmcif
-DISTVERSION=	0.79
+DISTVERSION=	0.81
 CATEGORIES=	science biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	mmCIF Core Access Library
 WWW=		https://mmcif.wwpdb.org/
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 PY_DEPENDS=	${PYTHON_PKGNAMEPREFIX}future>0:devel/py-future@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}msgpack>0:devel/py-msgpack@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>=2.25:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR}
 BUILD_DEPENDS=	${PY_DEPENDS} \
 		cmake:devel/cmake-core
 RUN_DEPENDS=	${PY_DEPENDS}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}coverage>0:devel/py-coverage@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tox>0:devel/py-tox@${PY_FLAVOR}
 
 USES=		bison python
 USE_PYTHON=	distutils concurrent autoplist pytest # tests fail to run, see https://github.com/rcsb/py-mmcif/issues/18
 
 .include <bsd.port.mk>
diff --git a/science/py-mmcif/distinfo b/science/py-mmcif/distinfo
index 9e1a3805df69..81637d3dcdb5 100644
--- a/science/py-mmcif/distinfo
+++ b/science/py-mmcif/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1664833599
-SHA256 (mmcif-0.79.tar.gz) = 1ee1d641b221b613b7d573f66782ee7d609cf75b86002a57050cd0bfde58ce43
-SIZE (mmcif-0.79.tar.gz) = 935983
+TIMESTAMP = 1681060498
+SHA256 (mmcif-0.81.tar.gz) = dbe686cbeb500bf04a3e73e2858e1285ab19530e24d230a6d74654f24178c379
+SIZE (mmcif-0.81.tar.gz) = 1667874