diff --git a/devel/py-QtPy/Makefile b/devel/py-QtPy/Makefile
index d8470fe7cd64..1bcbfdfd6b25 100644
--- a/devel/py-QtPy/Makefile
+++ b/devel/py-QtPy/Makefile
@@ -1,25 +1,26 @@
 PORTNAME=	QtPy
 DISTVERSION=	2.3.1
 PORTREVISION=	1
 CATEGORIES=	devel python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Abstraction layer on top of the various Qt bindings
 WWW=		https://github.com/spyder-ide/qtpy
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
+BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools>=42:devel/py-setuptools@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}wheel>0:devel/py-wheel@${PY_FLAVOR}
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}qt5-pyqt>0:devel/py-qt5-pyqt@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-cov>0:devel/py-pytest-cov@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-qt>0:devel/py-pytest-qt@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	pep517 autoplist pytest # 1 test fails, see https://github.com/spyder-ide/qtpy/issues/418
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>