diff --git a/databases/py-pymemcache/Makefile b/databases/py-pymemcache/Makefile
index 9681f0d2a88f..604b7184eced 100644
--- a/databases/py-pymemcache/Makefile
+++ b/databases/py-pymemcache/Makefile
@@ -1,24 +1,31 @@
 PORTNAME=	pymemcache
-PORTVERSION=	3.5.2
+PORTVERSION=	4.0.0
 CATEGORIES=	databases python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	ale_sagra@hotmail.com
 COMMENT=	Comprehensive, fast, pure-Python memcached client
 WWW=		https://github.com/pinterest/pymemcache
 
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR}
+TEST_DEPENDS=   ${PYTHON_PKGNAMEPREFIX}Faker>0:devel/py-Faker@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}pytest-cov>0:devel/py-pytest-cov@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}gevent>0:devel/py-gevent@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}pylibmc>0:databases/py-pylibmc@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}python-memcached>0:databases/py-python-memcached@${PY_FLAVOR} \
+                ${PYTHON_PKGNAMEPREFIX}zstd>0:archivers/py-zstd@${PY_FLAVOR}
 
 USES=		python:3.6+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
 
 do-test:
 	@cd ${WRKSRC} && ${PYTHON_CMD} -m pytest -rs -v
 
 .include <bsd.port.mk>
diff --git a/databases/py-pymemcache/distinfo b/databases/py-pymemcache/distinfo
index 410fe6fcc9f3..943ce1038b58 100644
--- a/databases/py-pymemcache/distinfo
+++ b/databases/py-pymemcache/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1648832243
-SHA256 (pymemcache-3.5.2.tar.gz) = 8923ab59840f0d5338f1c52dba229fa835545b91c3c2f691c118e678d0fb974e
-SIZE (pymemcache-3.5.2.tar.gz) = 65351
+TIMESTAMP = 1666026624
+SHA256 (pymemcache-4.0.0.tar.gz) = 27bf9bd1bbc1e20f83633208620d56de50f14185055e49504f4f5e94e94aff94
+SIZE (pymemcache-4.0.0.tar.gz) = 70176