diff --git a/biology/ngs-sdk/Makefile b/biology/ngs-sdk/Makefile
index 21517e76a934..8ac3c93758ab 100644
--- a/biology/ngs-sdk/Makefile
+++ b/biology/ngs-sdk/Makefile
@@ -1,44 +1,43 @@
 PORTNAME=	ngs
-DISTVERSION=	2.11.0
-PORTREVISION=	2
+DISTVERSION=	2.11.1
 CATEGORIES=	biology
 PKGNAMESUFFIX=	-sdk
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Tools and libraries for using data in the INSDC Sequence Read Archives
 
 LICENSE=	PD
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BROKEN_aarch64=		fails to configure: unsupported architecture 'FreeBSD'
 BROKEN_riscv64=		fails to configure: unsupported architecture 'FreeBSD'
 NOT_FOR_ARCHS=		powerpc64
 NOT_FOR_ARCHS_REASON=	os-arch.prl needs to be taught about powerpc64
 
 USES=		compiler:c++11-lang gmake perl5
 USE_PERL5=	build
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	ncbi
 
 HAS_CONFIGURE=	yes
 CONFIGURE_ARGS=	--prefix="${STAGEDIR}${PREFIX}" --build-prefix="${WRKSRC}/build"
 
 ALL_TARGET=	ngs-sdk
 
 post-extract:
 	@cd ${WRKSRC}/ngs-sdk/ngs/unix && ${LN} -s x86_64 amd64
 
 do-install: # install target from the project breaks: https://github.com/ncbi/ngs/issues/34
 	# install headers
 	cd ${WRKSRC}/ngs-sdk && ${COPYTREE_SHARE} ngs ${STAGEDIR}${PREFIX}/include
 	${RM} -r ${STAGEDIR}${PREFIX}/include/ngs/win
 	# install libraries
 	cd ${WRKSRC}/build/ngs-sdk/FreeBSD/clang/${ARCH}/rel/lib && ${COPYTREE_SHARE} . ${STAGEDIR}${PREFIX}/lib
 		# The above command installs broken-looking static libs with symlinks.
 		# This is intentional, see comments https://github.com/ncbi/ncbi-vdb/issues/36#issuecomment-817990790 This may change in future versions.
 	# strip
-	${STRIP_CMD} ${STAGEDIR}${PREFIX}/lib/libngs-sdk.so.2.11.0
+	${STRIP_CMD} ${STAGEDIR}${PREFIX}/lib/libngs-sdk.so.${DISTVERSION}
 
 .include <bsd.port.mk>
diff --git a/biology/ngs-sdk/distinfo b/biology/ngs-sdk/distinfo
index 5d95554582cb..2ce5d901ca91 100644
--- a/biology/ngs-sdk/distinfo
+++ b/biology/ngs-sdk/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1616222114
-SHA256 (ncbi-ngs-2.11.0_GH0.tar.gz) = 5fde50784760c00b403c2cc42ead15a4e9477697ee439f0a16edb4de3f52dfcc
-SIZE (ncbi-ngs-2.11.0_GH0.tar.gz) = 1100365
+TIMESTAMP = 1629303705
+SHA256 (ncbi-ngs-2.11.1_GH0.tar.gz) = f39c56bbfdb0bdacdd5e86b5d3b65c448df17e419f3f533b1a0168e99f532553
+SIZE (ncbi-ngs-2.11.1_GH0.tar.gz) = 1101141
diff --git a/biology/ngs-sdk/files/patch-ngs-sdk_setup_konfigure.perl b/biology/ngs-sdk/files/patch-ngs-sdk_setup_konfigure.perl
index ef1f8a936a62..5fc8fb532a2c 100644
--- a/biology/ngs-sdk/files/patch-ngs-sdk_setup_konfigure.perl
+++ b/biology/ngs-sdk/files/patch-ngs-sdk_setup_konfigure.perl
@@ -1,55 +1,37 @@
---- ngs-sdk/setup/konfigure.perl.orig	2021-03-15 18:08:20 UTC
+--- ngs-sdk/setup/konfigure.perl.orig	2021-08-18 16:26:23 UTC
 +++ ngs-sdk/setup/konfigure.perl
-@@ -204,7 +204,7 @@ print "checking system type... " unless ($AUTORUN);
- my ($OS, $ARCH, $OSTYPE, $MARCH, @ARCHITECTURES) = OsArch();
- println $OSTYPE unless ($AUTORUN);
- 
--unless ($OSTYPE =~ /linux/i || $OSTYPE =~ /darwin/i || $OSTYPE eq 'win') {
-+unless ($OSTYPE =~ /linux/i || $OSTYPE =~ /freebsd/i || $OSTYPE =~ /darwin/i || $OSTYPE eq 'win') {
-     println "configure: error: unsupported system '$OSTYPE'";
-     exit 1;
- }
 @@ -225,7 +225,7 @@ if ($OS eq 'linux') {
  
  print "checking machine architecture... " unless ($AUTORUN);
  println $MARCH unless ($AUTORUN);
 -unless ($MARCH =~ /x86_64/i || $MARCH =~ /i?86/i || $MARCH =~ /aarch64/) {
 +unless ($MARCH =~ /x86_64/i || $MARCH =~ /amd64/i || $MARCH =~ /i?86/i || $MARCH =~ /aarch64/) {
      println "configure: error: unsupported architecture '$OSTYPE':'$MARCH'";
      exit 1;
  }
 @@ -312,6 +312,8 @@ my $BITS;
  
  if ($MARCH =~ /x86_64/i) {
      $BITS = 64;
 +} elsif ($MARCH =~ /amd64/i) {
 +    $BITS = 64;
  } elsif ($MARCH eq 'fat86') {
      $BITS = '32_64';
  } elsif ($MARCH =~ /i?86/i) {
-@@ -337,6 +339,25 @@ if ($OSTYPE =~ /linux/i) {
+@@ -337,6 +339,16 @@ if ($OSTYPE =~ /linux/i) {
      $OSINC = 'unix';
      $TOOLS = 'gcc' unless ($TOOLS);
      $PYTHON = 'python';
 +} elsif ($OSTYPE =~ /freebsd/i) {
 +    $LPFX = 'lib';
 +    $OBJX = 'o';
 +    $LOBX = 'pic.o';
 +    $LIBX = 'a';
 +    $SHLX = 'so';
 +    $EXEX = '';
 +    $OSINC = 'unix';
 +    $TOOLS = 'clang' unless ($TOOLS);
 +    $PYTHON = $ENV{FREEBSD_PYTHON_CMD};
-+} elsif ($OSTYPE =~ /darwin/i) {
-+    $LPFX = 'lib';
-+    $OBJX = 'o';
-+    $LOBX = 'pic.o';
-+    $LIBX = 'a';
-+    $SHLX = 'dylib';
-+    $EXEX = '';
-+    $OSINC = 'unix';
-+    $TOOLS = 'clang' unless ($TOOLS);
  } elsif ($OSTYPE =~ /darwin/i) {
      $LPFX = 'lib';
      $OBJX = 'o';
diff --git a/biology/ngs-sdk/pkg-plist b/biology/ngs-sdk/pkg-plist
index 93a82bd6b5e9..4b46d04f486c 100644
--- a/biology/ngs-sdk/pkg-plist
+++ b/biology/ngs-sdk/pkg-plist
@@ -1,100 +1,100 @@
 include/ngs/Alignment.hpp
 include/ngs/AlignmentIterator.hpp
 include/ngs/ErrorMsg.hpp
 include/ngs/Fragment.hpp
 include/ngs/FragmentIterator.hpp
 include/ngs/Package.hpp
 include/ngs/Pileup.hpp
 include/ngs/PileupEvent.hpp
 include/ngs/PileupEventIterator.hpp
 include/ngs/PileupIterator.hpp
 include/ngs/Read.hpp
 include/ngs/ReadCollection.hpp
 include/ngs/ReadGroup.hpp
 include/ngs/ReadGroupIterator.hpp
 include/ngs/ReadIterator.hpp
 include/ngs/Reference.hpp
 include/ngs/ReferenceIterator.hpp
 include/ngs/ReferenceSequence.hpp
 include/ngs/Statistics.hpp
 include/ngs/StringRef.hpp
 include/ngs/adapter/AlignmentItf.hpp
 include/ngs/adapter/ErrorMsg.hpp
 include/ngs/adapter/FragmentItf.hpp
 include/ngs/adapter/PileupEventItf.hpp
 include/ngs/adapter/PileupItf.hpp
 include/ngs/adapter/ReadCollectionItf.hpp
 include/ngs/adapter/ReadGroupItf.hpp
 include/ngs/adapter/ReadItf.hpp
 include/ngs/adapter/Refcount.hpp
 include/ngs/adapter/ReferenceItf.hpp
 include/ngs/adapter/ReferenceSequenceItf.hpp
 include/ngs/adapter/StatisticsItf.hpp
 include/ngs/adapter/StringItf.hpp
 include/ngs/adapter/defs.h
 include/ngs/inl/Alignment.hpp
 include/ngs/inl/AlignmentIterator.hpp
 include/ngs/inl/Fragment.hpp
 include/ngs/inl/FragmentIterator.hpp
 include/ngs/inl/Package.hpp
 include/ngs/inl/Pileup.hpp
 include/ngs/inl/PileupEvent.hpp
 include/ngs/inl/PileupEventIterator.hpp
 include/ngs/inl/PileupIterator.hpp
 include/ngs/inl/Read.hpp
 include/ngs/inl/ReadCollection.hpp
 include/ngs/inl/ReadGroup.hpp
 include/ngs/inl/ReadGroupIterator.hpp
 include/ngs/inl/ReadIterator.hpp
 include/ngs/inl/Reference.hpp
 include/ngs/inl/ReferenceIterator.hpp
 include/ngs/inl/ReferenceSequence.hpp
 include/ngs/inl/Statistics.hpp
 include/ngs/inl/StringRef.hpp
 include/ngs/itf/AlignmentItf.h
 include/ngs/itf/AlignmentItf.hpp
 include/ngs/itf/ErrBlock.h
 include/ngs/itf/ErrBlock.hpp
 include/ngs/itf/ErrorMsg.hpp
 include/ngs/itf/FragmentItf.h
 include/ngs/itf/FragmentItf.hpp
 include/ngs/itf/PackageItf.hpp
 include/ngs/itf/PileupEventItf.h
 include/ngs/itf/PileupEventItf.hpp
 include/ngs/itf/PileupItf.h
 include/ngs/itf/PileupItf.hpp
 include/ngs/itf/ReadCollectionItf.h
 include/ngs/itf/ReadCollectionItf.hpp
 include/ngs/itf/ReadGroupItf.h
 include/ngs/itf/ReadGroupItf.hpp
 include/ngs/itf/ReadItf.h
 include/ngs/itf/ReadItf.hpp
 include/ngs/itf/Refcount.h
 include/ngs/itf/Refcount.hpp
 include/ngs/itf/ReferenceItf.h
 include/ngs/itf/ReferenceItf.hpp
 include/ngs/itf/ReferenceSequenceItf.h
 include/ngs/itf/ReferenceSequenceItf.hpp
 include/ngs/itf/StatisticsItf.h
 include/ngs/itf/StatisticsItf.hpp
 include/ngs/itf/StringItf.h
 include/ngs/itf/StringItf.hpp
 include/ngs/itf/VTable.h
 include/ngs/itf/VTable.hpp
 include/ngs/itf/defs.h
 include/ngs/unix/amd64
 include/ngs/unix/arm64/atomic32.h
 include/ngs/unix/fat86/atomic32.h
 include/ngs/unix/i386/atomic32.h
 include/ngs/unix/x86_64/atomic32.h
 lib/libngs-adapt-c++-static.a
 lib/libngs-adapt-c++.a
 lib/libngs-adapt-c++.a.2
-lib/libngs-adapt-c++.a.2.11.0
+lib/libngs-adapt-c++.a.2.11.1
 lib/libngs-c++-static.a
 lib/libngs-c++.a
 lib/libngs-c++.a.2
-lib/libngs-c++.a.2.11.0
+lib/libngs-c++.a.2.11.1
 lib/libngs-sdk.so
 lib/libngs-sdk.so.2
-lib/libngs-sdk.so.2.11.0
+lib/libngs-sdk.so.2.11.1