diff --git a/devel/py-grpcio-tools/Makefile b/devel/py-grpcio-tools/Makefile
index 3e2b0857031e..fc7498dfefe8 100644
--- a/devel/py-grpcio-tools/Makefile
+++ b/devel/py-grpcio-tools/Makefile
@@ -1,24 +1,24 @@
 PORTNAME=	grpcio-tools
-PORTVERSION=	1.48.1
+PORTVERSION=	1.49.0
 CATEGORIES=	devel python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	vanilla@FreeBSD.org
 COMMENT=	Protobuf code generator for gRPC
 WWW=		https://pypi.org/project/grpcio-tools/
 
 LICENSE=	BSD3CLAUSE
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}grpcio>1:devel/py-grpcio@${PY_FLAVOR}
 LIB_DEPENDS=	libcares.so:dns/c-ares
 
 USES=		compiler:c++11-lang localbase:ldflags python:3.5+
 USE_PYTHON=	autoplist distutils
 CFLAGS+=	-DHAVE_PTHREAD=1
 LDFLAGS+=	-lcares
 
 post-install:
 	${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/grpc_tools/_protoc_compiler*.so
 
 .include <bsd.port.mk>
diff --git a/devel/py-grpcio-tools/distinfo b/devel/py-grpcio-tools/distinfo
index 64798e0caa7a..82ca0c0a8b98 100644
--- a/devel/py-grpcio-tools/distinfo
+++ b/devel/py-grpcio-tools/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1662189801
-SHA256 (grpcio-tools-1.48.1.tar.gz) = 1178f2ea531f80cc2027ec64728df6ffc8e98cf1df61652a496eafd612127183
-SIZE (grpcio-tools-1.48.1.tar.gz) = 2236762
+TIMESTAMP = 1663507524
+SHA256 (grpcio-tools-1.49.0.tar.gz) = 16ac93ac515194f63febcf6f8a96a7f17390268972acc15e765d257f5008f2af
+SIZE (grpcio-tools-1.49.0.tar.gz) = 2238106
diff --git a/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_io_coded__stream.h b/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_io_coded__stream.h
deleted file mode 100644
index 15283972c1bc..000000000000
--- a/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_io_coded__stream.h
+++ /dev/null
@@ -1,11 +0,0 @@
---- third_party/protobuf/src/google/protobuf/io/coded_stream.h.orig	2021-04-10 02:54:14 UTC
-+++ third_party/protobuf/src/google/protobuf/io/coded_stream.h
-@@ -131,7 +131,7 @@
- #pragma runtime_checks("c", off)
- #endif
- #else
--#ifdef __APPLE__
-+#if defined(__APPLE__) || defined(__FreeBSD__)
- #include <machine/endian.h>  // __BYTE_ORDER
- #else
- #include <endian.h>  // __BYTE_ORDER
diff --git a/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_stubs_port.h b/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_stubs_port.h
deleted file mode 100644
index 1c2591d13e2e..000000000000
--- a/devel/py-grpcio-tools/files/patch-third__party_protobuf_src_google_protobuf_stubs_port.h
+++ /dev/null
@@ -1,11 +0,0 @@
---- third_party/protobuf/src/google/protobuf/stubs/port.h.orig	2021-04-10 02:52:06 UTC
-+++ third_party/protobuf/src/google/protobuf/stubs/port.h
-@@ -57,7 +57,7 @@
- #pragma runtime_checks("c", off)
- #endif
- #else
--#ifdef __APPLE__
-+#if defined(__APPLE__) || defined(__FreeBSD__)
- #include <machine/endian.h>  // __BYTE_ORDER
- #else
- #include <endian.h>  // __BYTE_ORDER