diff --git a/science/libcifpp/Makefile b/science/libcifpp/Makefile
index 1928040685c6..c330d2598fff 100644
--- a/science/libcifpp/Makefile
+++ b/science/libcifpp/Makefile
@@ -1,37 +1,37 @@
 PORTNAME=	libcifpp
 DISTVERSIONPREFIX=	v
-DISTVERSION=	5.0.9
+DISTVERSION=	5.1.0.1
 CATEGORIES=	science
 MASTER_SITES=	ftp://ftp.wwpdb.org/pub/pdb/data/monomers/:components
 DISTFILES=	components.cif.gz:components
 DIST_SUBDIR=	${PORTNAME}-${PORTVERSION}
 EXTRACT_ONLY=	${GH_ACCOUNT}-${GH_PROJECT}-${DISTVERSIONFULL}_GH0${EXTRACT_SUFX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Library to manipulate mmCIF and PDB files
 WWW=		https://github.com/PDB-REDO/libcifpp
 
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 LIB_DEPENDS=	libboost_iostreams.so:devel/boost-libs
 RUN_DEPENDS=	bash:shells/bash
 
 USES=		cmake:testing compiler:c++20-lang eigen:3 shebangfix
 USE_LDCONFIG=	yes
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	PDB-REDO
 
 SHEBANG_FILES=	tools/update-libcifpp-data.in
 
 CMAKE_ON=	BUILD_SHARED_LIBS
 CMAKE_ARGS=	-DDISTDIR_FULL=${DISTDIR}/${DIST_SUBDIR}
 CMAKE_TESTING_ON=	ENABLE_TESTING
 
 post-install:
 	@cd ${STAGEDIR}${PREFIX} && \
 		${RM} -r var etc/libcifpp etc/periodic
 	@${RM} -r ${STAGEDIR}/var/cache/libcifpp
 
 .include <bsd.port.mk>
diff --git a/science/libcifpp/distinfo b/science/libcifpp/distinfo
index 08c8532cd033..8ac4ec928512 100644
--- a/science/libcifpp/distinfo
+++ b/science/libcifpp/distinfo
@@ -1,5 +1,5 @@
-TIMESTAMP = 1685771829
-SHA256 (libcifpp-5.0.9/components.cif.gz) = 9b80eb00bfd9701c574d9773e59fda9dfa8310b3c6d9a43ff205f431abe5f076
-SIZE (libcifpp-5.0.9/components.cif.gz) = 91711088
-SHA256 (libcifpp-5.0.9/PDB-REDO-libcifpp-v5.0.9_GH0.tar.gz) = 9c6734a5f1332153e8f2bcfdcdd3c1b0e067ce859079c474ab0ef5a629ae9121
-SIZE (libcifpp-5.0.9/PDB-REDO-libcifpp-v5.0.9_GH0.tar.gz) = 2240381
+TIMESTAMP = 1686278070
+SHA256 (libcifpp-5.1.0.1/components.cif.gz) = 67f5df6e2a08e0ad407215e771d99aec61e1a050750cb6d0c6ceecf531d18552
+SIZE (libcifpp-5.1.0.1/components.cif.gz) = 91858947
+SHA256 (libcifpp-5.1.0.1/PDB-REDO-libcifpp-v5.1.0.1_GH0.tar.gz) = ae2cdf7851d1be4ef1fa5bdaf9abbc7d01df9d0935ae8baf9d6335577445d74b
+SIZE (libcifpp-5.1.0.1/PDB-REDO-libcifpp-v5.1.0.1_GH0.tar.gz) = 2242975
diff --git a/science/libcifpp/pkg-plist b/science/libcifpp/pkg-plist
index 30db3b4b5fbd..c28a15a76e9a 100644
--- a/science/libcifpp/pkg-plist
+++ b/science/libcifpp/pkg-plist
@@ -1,41 +1,41 @@
 etc/libcifpp.conf
 include/cif++.hpp
 include/cif++/atom_type.hpp
 include/cif++/category.hpp
 include/cif++/compound.hpp
 include/cif++/condition.hpp
 include/cif++/datablock.hpp
 include/cif++/dictionary_parser.hpp
 include/cif++/exports.hpp
 include/cif++/file.hpp
 include/cif++/format.hpp
 include/cif++/forward_decl.hpp
 include/cif++/gzio.hpp
 include/cif++/item.hpp
 include/cif++/iterator.hpp
 include/cif++/matrix.hpp
 include/cif++/model.hpp
 include/cif++/parser.hpp
 include/cif++/pdb/cif2pdb.hpp
 include/cif++/pdb/io.hpp
 include/cif++/pdb/pdb2cif.hpp
 include/cif++/pdb/pdb2cif_remark_3.hpp
 include/cif++/pdb/tls.hpp
 include/cif++/point.hpp
 include/cif++/row.hpp
 include/cif++/symmetry.hpp
 include/cif++/text.hpp
 include/cif++/utilities.hpp
 include/cif++/validate.hpp
 lib/cmake/cifpp/cifppConfig.cmake
 lib/cmake/cifpp/cifppConfigVersion.cmake
 lib/cmake/cifpp/cifppTargets-%%CMAKE_BUILD_TYPE%%.cmake
 lib/cmake/cifpp/cifppTargets.cmake
 lib/libcifpp.so
 lib/libcifpp.so.5
-lib/libcifpp.so.5.0.9
+lib/libcifpp.so.5.1.0.1
 libdata/pkgconfig/libcifpp.pc
 %%DATADIR%%/components.cif
 %%DATADIR%%/mmcif_ddl.dic
 %%DATADIR%%/mmcif_ma.dic
 %%DATADIR%%/mmcif_pdbx.dic