diff --git a/math/py-Pyomo/Makefile b/math/py-Pyomo/Makefile
index 962376ec915a..3741e88b0189 100644
--- a/math/py-Pyomo/Makefile
+++ b/math/py-Pyomo/Makefile
@@ -1,38 +1,56 @@
 PORTNAME=	Pyomo
-DISTVERSION=	6.8.1
-PORTREVISION=	1
+DISTVERSION=	6.10.1
 CATEGORIES=	math python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Python Optimization Modeling Objects
 WWW=		https://github.com/Pyomo/pyomo \
 		https://www.pyomo.org/
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 LIB_DEPENDS=	libCbc.so:math/cbc # this library is loaded dynamically
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}ply>0:devel/py-ply@${PY_FLAVOR} \
 		glpsol:math/glpk
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}coverage>0:devel/py-coverage@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}parameterized>0:devel/py-parameterized@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pybind11>0:devel/py-pybind11@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytest-parallel>0:devel/py-pytest-parallel@${PY_FLAVOR}
 TEST_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}docplex>0:math/py-docplex@${PY_FLAVOR} \
 		casadi>0:math/casadi \
 		ipopt:math/ipopt
 
 USES=		python
 USE_PYTHON=	distutils cython concurrent autoplist pytest # tests fail to run, see https://github.com/Pyomo/pyomo/issues/3424
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
+# disable failing tests, see https://github.com/Pyomo/pyomo/issues/3999
+TEST_ARGS=	--ignore=pyomo/contrib/sensitivity_toolbox/tests/test_sens.py \
+		--ignore=pyomo/contrib/doe/tests \
+		--ignore=examples/pyomobook/test_book_examples.py \
+		--ignore=pyomo/contrib/parmest/tests \
+		--ignore=doc/OnlineDocs/tests/test_examples.py \
+		--ignore=pyomo/contrib/pyros/tests/test_grcs.py \
+		--ignore=pyomo/environ/tests/test_environ.py \
+		--ignore=pyomo/common/tests/test_tee.py \
+		--ignore=pyomo/common/tests/test_log.py \
+		--ignore=pyomo/common/tests/test_deprecated.py \
+		--ignore=pyomo/core/tests/examples/test_pyomo.py \
+		--ignore=pyomo/contrib/cspline_external/test/test_parameter_calculation.py \
+		--ignore=pyomo/contrib/solver/tests/solvers/test_ipopt.py \
+		-ignore=pyomo/dae/tests/test_colloc.py \
+		--ignore=pyomo/contrib/multistart/tests/test_multi.py
 
 USE_GITHUB=	yes
 GH_PROJECT=	pyomo
 
 NO_ARCH=	yes
 
 BINARY_ALIAS=	python=${PYTHON_CMD} # for tests
 
+# tests as of 6.10.1: 9321 passed, 7031 skipped, 1743 deselected, 25 xfailed, 15 warnings in 1355.67s (0:22:35) (with failing tests disabled)
+# tests as of 6.10.1: 94 failed, 9857 passed, 7170 skipped, 1749 deselected, 25 xfailed, 15 warnings in 571.45s (0:09:31) (with failig tests enabled)
+
 .include <bsd.port.mk>
diff --git a/math/py-Pyomo/distinfo b/math/py-Pyomo/distinfo
index 8b48984df1c1..c3e89d6e65c2 100644
--- a/math/py-Pyomo/distinfo
+++ b/math/py-Pyomo/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1731745977
-SHA256 (Pyomo-pyomo-6.8.1_GH0.tar.gz) = cd24e7de15e14ef12f75bd227b1f6af8c6f0c9499f04b837d70092236010904a
-SIZE (Pyomo-pyomo-6.8.1_GH0.tar.gz) = 15043858
+TIMESTAMP = 1784748678
+SHA256 (Pyomo-pyomo-6.10.1_GH0.tar.gz) = 8f37fb977387ecf0c65d9c27cc017fe49bf5154a5eeda0c0a0bc0b6fbde768a0
+SIZE (Pyomo-pyomo-6.10.1_GH0.tar.gz) = 16519384
diff --git a/math/py-Pyomo/files/patch-pyproject.toml b/math/py-Pyomo/files/patch-pyproject.toml
new file mode 100644
index 000000000000..4ac7fd16a3de
--- /dev/null
+++ b/math/py-Pyomo/files/patch-pyproject.toml
@@ -0,0 +1,22 @@
+--- pyproject.toml.orig	2026-07-22 22:03:21 UTC
++++ pyproject.toml
+@@ -1,7 +1,7 @@ requires = [
+ [build-system]
+ requires = [
+     # setuptools 77 for core-metadata version 2.4
+-    "setuptools>=77",
++    "setuptools>=61.0",
+     "wheel",
+     # leave Cython as an optional, runtime‑selectable extra
+     # setuptools will still import it from setup.py when requested
+@@ -16,8 +16,8 @@ readme = "README.md"
+ name = "pyomo"
+ description = "The Pyomo optimization modeling framework"
+ readme = "README.md"
+-license = "BSD-3-Clause"
+-license-files = [ "LICENSE.md" ]
++license = {text = "BSD-3-Clause"}
++# license-files removed
+ authors = [{name = "Pyomo Development Team", email = "pyomo-developers@googlegroups.com"}]
+ requires-python = ">=3.10"
+ keywords=['optimization']