diff --git a/math/py-rpy2/Makefile b/math/py-rpy2/Makefile
index c50b78e7cc85..c84f3a52aab2 100644
--- a/math/py-rpy2/Makefile
+++ b/math/py-rpy2/Makefile
@@ -1,49 +1,49 @@
 PORTNAME=	rpy2
-PORTVERSION=	3.5.2
+PORTVERSION=	3.5.3
 CATEGORIES=	math python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	sunpoet@FreeBSD.org
 COMMENT=	Python interface to the R Programming Language
 
 LICENSE=	GPLv2+
 LICENSE_FILE=	${WRKSRC}/gpl-2.0.txt
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR}
 LIB_DEPENDS=	libR.so:math/R \
 		libicui18n.so:devel/icu \
 		libpcre2-8.so:devel/pcre2
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}cffi>=1.10.0:devel/py-cffi@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=0:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pytz>=0,1,1:devel/py-pytz@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tzlocal>=0:devel/py-tzlocal@${PY_FLAVOR}
 
 USES=		compiler:c11 fortran python:3.7+ readline
 USE_PYTHON=	autoplist concurrent distutils
 
 MAKE_ENV=	RPY2_CFFI_MODE=BOTH
 
 PLIST_FILES=	${PYTHON_SITELIBDIR}/__pycache__/_rinterface_cffi_abi.cpython-${PYTHON_SUFFIX}.opt-1.pyc \
 		${PYTHON_SITELIBDIR}/__pycache__/_rinterface_cffi_abi.cpython-${PYTHON_SUFFIX}.pyc \
 		${PYTHON_SITELIBDIR}/_rinterface_cffi_abi.py
 
 OPTIONS_DEFINE=	NUMPY PANDAS
 OPTIONS_DEFAULT=NUMPY PANDAS
 NUMPY_DESC=	NumPy support
 PANDAS_DESC=	Pandas support
 
 NUMPY_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pandas>=0,1:math/py-pandas@${PY_FLAVOR}
 PANDAS_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}numpy>=0,1:math/py-numpy@${PY_FLAVOR} \
 			${PYTHON_PKGNAMEPREFIX}pandas>=0,1:math/py-pandas@${PY_FLAVOR}
 
 .include <bsd.port.pre.mk>
 
 .if ${PYTHON_REL} < 30800
 RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}typing-extensions>=0:devel/py-typing-extensions@${PY_FLAVOR}
 .endif
 
 post-install:
 	${FIND} ${STAGEDIR}${PYTHON_SITELIBDIR} -name '*.so' -exec ${STRIP_CMD} {} +
 
 .include <bsd.port.post.mk>
diff --git a/math/py-rpy2/distinfo b/math/py-rpy2/distinfo
index 1ea3cd688dff..f1658a0dce1b 100644
--- a/math/py-rpy2/distinfo
+++ b/math/py-rpy2/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1653926006
-SHA256 (rpy2-3.5.2.tar.gz) = 45ee00fdbad0b481c39369fb315651ddf854cf4ad56d24b7dcb3c74e135bd10e
-SIZE (rpy2-3.5.2.tar.gz) = 202826
+TIMESTAMP = 1659161195
+SHA256 (rpy2-3.5.3.tar.gz) = 53a092d48b44f46428fb30cb3155664d6d2f7af08ebc4c45df98df4c45a42ccb
+SIZE (rpy2-3.5.3.tar.gz) = 203939