diff --git a/biology/tRNAscan-SE/Makefile b/biology/tRNAscan-SE/Makefile
index a4155745402e..09d63d0e8e7f 100644
--- a/biology/tRNAscan-SE/Makefile
+++ b/biology/tRNAscan-SE/Makefile
@@ -1,27 +1,26 @@
 # Created by: chuynh@biolateral.com.au
 # $FreeBSD$
 
 PORTNAME=	tRNAscan-SE
-PORTVERSION=	2.0.0
-PORTREVISION=	1
+PORTVERSION=	2.0.3
 CATEGORIES=	biology
-MASTER_SITES=	http://lowelab.ucsc.edu/software/
+MASTER_SITES=	http://trna.ucsc.edu/software/
 DISTFILES=	${DISTNAME:tl}${EXTRACT_SUFX}
 
 MAINTAINER=	mzaki@niid.go.jp
 COMMENT=	Searching for tRNA genes in genomic sequence
 
 LICENSE=	GPLv3+
 LICENSE_FILE=	${WRKSRC}/COPYING
 
 RUN_DEPENDS=	cmsearch:biology/infernal
 
-WRKSRC=		${WRKDIR}/${DISTNAME:S,.0$,,}
+WRKSRC=		${WRKDIR}/${DISTNAME:C,\.[0-9]+$,,}
 
 GNU_CONFIGURE=	yes
 
 USES=		perl5 autoreconf
 
 MAKE_JOBS_UNSAFE=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/tRNAscan-SE/distinfo b/biology/tRNAscan-SE/distinfo
index fce995d4414e..2608d37c82f6 100644
--- a/biology/tRNAscan-SE/distinfo
+++ b/biology/tRNAscan-SE/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1528270436
-SHA256 (trnascan-se-2.0.0.tar.gz) = 0dde1c07142e4bf77b21d53ddf3eeb1ef8c52248005a42323d13f8d7c798100c
-SIZE (trnascan-se-2.0.0.tar.gz) = 4372755
+TIMESTAMP = 1557725777
+SHA256 (trnascan-se-2.0.3.tar.gz) = b305c1bf226d16833349b22ad1f3160a52ad30f577a336128da3cc76d5772a4e
+SIZE (trnascan-se-2.0.3.tar.gz) = 4372985
diff --git a/biology/tRNAscan-SE/files/patch-tRNAscan-SE.src b/biology/tRNAscan-SE/files/patch-tRNAscan-SE.src
index 8bb7d492e25f..1ccb6ae31d0f 100644
--- a/biology/tRNAscan-SE/files/patch-tRNAscan-SE.src
+++ b/biology/tRNAscan-SE/files/patch-tRNAscan-SE.src
@@ -1,17 +1,11 @@
---- tRNAscan-SE.src.orig	2017-12-03 01:59:25 UTC
+--- tRNAscan-SE.src.orig	2019-04-30 21:37:37 UTC
 +++ tRNAscan-SE.src
-@@ -1,4 +1,4 @@
--#! /usr/bin/perl
-+#! @PERL@
- #
- # --------------------------------------------------------------------
- # tRNAscan-SE: a program for improved detection of transfer RNA
-@@ -44,7 +44,7 @@ our $release_date = "December 2017";
+@@ -44,7 +44,7 @@ our $release_date = "April 2019";
  our $program_id = "tRNAscan-SE-".$version;
  
  # modified by 'make'
 -our $default_conf = "@bindir@/tRNAscan-SE.conf";
 +our $default_conf = "@sysconfdir@/tRNAscan-SE.conf";
  
  # Signal handling
  $SIG{'TERM'} = 'error_handler';