diff --git a/biology/seqan3/Makefile b/biology/seqan3/Makefile
index c1675008fd19..bdaa8f7f8e88 100644
--- a/biology/seqan3/Makefile
+++ b/biology/seqan3/Makefile
@@ -1,45 +1,51 @@
 PORTNAME=	seqan3
-DISTVERSION=	3.4.0
+DISTVERSION=	3.4.2
 CATEGORIES=	biology devel math
-MASTER_SITES=	https://github.com/cpm-cmake/CPM.cmake/releases/download/v0.42.0/:cpm
+MASTER_SITES=	https://github.com/cpm-cmake/CPM.cmake/releases/download/v0.42.1/:cpm
 DISTFILES=	CPM.cmake:cpm
 DIST_SUBDIR=	${PORTNAME}-${DISTVERSION}
 EXTRACT_ONLY=	${DISTNAME}${EXTRACT_SUFX} \
 		xxsds-sdsl-lite-d54d389_GH0${EXTRACT_SUFX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	C++ header-only library for biological sequence analysis
 WWW=		https://www.seqan.de/ \
 		https://github.com/seqan/seqan3
 
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.md
 
 HPP_DEPENDS=	cereal>0:devel/cereal \
 		range-v3>0:devel/range-v3
 BUILD_DEPENDS=	${HPP_DEPENDS}
 RUN_DEPENDS=	${HPP_DEPENDS} \
 		coin-or-lemon>0:math/lemon
 
 USES=		cmake compiler:c++23-lang localbase
 
 USE_GITHUB=	yes
 GH_ACCOUNT=	seqan
 GH_TUPLE=	xxsds:sdsl-lite:d54d389:sdsl_lite/submodules/sdsl-lite
 
 CMAKE_ARGS=	-DCPM_LOCATION=${DISTDIR}/${DIST_SUBDIR}
 
 TEST_WRKSRC=	${WRKSRC}/.test
 
 NO_ARCH=	yes
 
+xpost-patch:
+	# remove CPM.cmake: it triggers undesirable logic in cmake scripts
+	@${RM} ${WRKSRC}/cmake/CPM.cmake
+
 post-install:
 	@${RM} -r ${STAGEDIR}${DOCSDIR}
 
 do-test:
 	@${MKDIR} ${TEST_WRKSRC} && cd ${TEST_WRKSRC} && \
 		${SETENV} ${CONFIGURE_ENV} ${CMAKE_BIN} ${CMAKE_ARGS} -DFETCHCONTENT_FULLY_DISCONNECTED=OFF ${WRKSRC}/test/unit && \
 		${SETENV} ${MAKE_ENV} ${MAKE_CMD} ${MAKE_ARGS} ${ALL_TARGET} && \
 		ctest
 
+# tests as of 3.4.2: 96% tests passed, 14 tests failed out of 315: some tests fail wuth SIGILL, see https://github.com/seqan/seqan3/issues/3415, other tests also fail, see https://github.com/seqan/seqan3/issues/3416
+
 .include <bsd.port.mk>
diff --git a/biology/seqan3/distinfo b/biology/seqan3/distinfo
index 9e9fe56de4ee..3d3ebb3710dc 100644
--- a/biology/seqan3/distinfo
+++ b/biology/seqan3/distinfo
@@ -1,7 +1,7 @@
-TIMESTAMP = 1756395731
-SHA256 (seqan3-3.4.0/CPM.cmake) = 2020b4fc42dba44817983e06342e682ecfc3d2f484a581f11cc5731fbe4dce8a
-SIZE (seqan3-3.4.0/CPM.cmake) = 44969
-SHA256 (seqan3-3.4.0/seqan-seqan3-3.4.0_GH0.tar.gz) = 8e000e6788f1e2ada071b36f64231d56f18e2d687ab4122d86cd3aefc6c87743
-SIZE (seqan3-3.4.0/seqan-seqan3-3.4.0_GH0.tar.gz) = 1749810
-SHA256 (seqan3-3.4.0/xxsds-sdsl-lite-d54d389_GH0.tar.gz) = eaac28144b34a833afb8c03139abbe427d4b95a827bf5b9b6532353f9cff9ec1
-SIZE (seqan3-3.4.0/xxsds-sdsl-lite-d54d389_GH0.tar.gz) = 1183835
+TIMESTAMP = 1776139326
+SHA256 (seqan3-3.4.2/CPM.cmake) = f3a6dcc6a04ce9e7f51a127307fa4f699fb2bade357a8eb4c5b45df76e1dc6a5
+SIZE (seqan3-3.4.2/CPM.cmake) = 44969
+SHA256 (seqan3-3.4.2/seqan-seqan3-3.4.2_GH0.tar.gz) = bb7467f8e296279a89fa75909129e128d67195187fe066ed096e9fb6250e37e5
+SIZE (seqan3-3.4.2/seqan-seqan3-3.4.2_GH0.tar.gz) = 1752849
+SHA256 (seqan3-3.4.2/xxsds-sdsl-lite-d54d389_GH0.tar.gz) = eaac28144b34a833afb8c03139abbe427d4b95a827bf5b9b6532353f9cff9ec1
+SIZE (seqan3-3.4.2/xxsds-sdsl-lite-d54d389_GH0.tar.gz) = 1183835