diff --git a/biology/vsearch/Makefile b/biology/vsearch/Makefile
index f8a7817ace1c..57d2800ca9fc 100644
--- a/biology/vsearch/Makefile
+++ b/biology/vsearch/Makefile
@@ -1,30 +1,28 @@
 PORTNAME=		vsearch
 DISTVERSIONPREFIX=	v
-DISTVERSION=		2.23.0
+DISTVERSION=		2.24.0
 CATEGORIES=		biology
 
 MAINTAINER=	jwb@FreeBSD.org
 COMMENT=	Versatile open-source tool for metagenomics
 WWW=		https://github.com/torognes/vsearch
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 ONLY_FOR_ARCHS=		aarch64 amd64 powerpc64le
 ONLY_FOR_ARCHS_REASON=	Explicitly enumerated by upstream developers
 
-LIB_DEPENDS=	libsysinfo.so:devel/libsysinfo
-
 USES=		autoreconf ghostscript:build gmake localbase
 USE_GITHUB=	yes
 
 GH_ACCOUNT=	torognes
 GNU_CONFIGURE=	yes
 
 PLIST_FILES=	bin/vsearch man/man1/vsearch.1.gz
 PORTDOCS=	*
 
 OPTIONS_DEFINE=	DOCS
 OPTIONS_SUB=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/vsearch/distinfo b/biology/vsearch/distinfo
index 05ae4719dd7e..8cf35e86430e 100644
--- a/biology/vsearch/distinfo
+++ b/biology/vsearch/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1688839144
-SHA256 (torognes-vsearch-v2.23.0_GH0.tar.gz) = 4686e35e1d8488ffedb4c6dd4de9b6eccc94f337d7b86e1759d932bce59c9b64
-SIZE (torognes-vsearch-v2.23.0_GH0.tar.gz) = 266534
+TIMESTAMP = 1698407468
+SHA256 (torognes-vsearch-v2.24.0_GH0.tar.gz) = 036c3a5c7827958446e56155d750d22d03d460a53237c37fa6541208dc0bdca1
+SIZE (torognes-vsearch-v2.24.0_GH0.tar.gz) = 267096
diff --git a/biology/vsearch/files/patch-src_vsearch.h b/biology/vsearch/files/patch-src_vsearch.h
new file mode 100644
index 000000000000..066f4488212d
--- /dev/null
+++ b/biology/vsearch/files/patch-src_vsearch.h
@@ -0,0 +1,10 @@
+--- src/vsearch.h.orig	2023-10-27 12:44:35 UTC
++++ src/vsearch.h
+@@ -161,7 +161,6 @@
+ #elif __FreeBSD__
+ 
+ #define PROG_OS "freebsd"
+-#include <sys/sysinfo.h>
+ #include <sys/resource.h>
+ #include <sys/endian.h>
+ #define bswap_16(x) bswap16(x)