diff --git a/biology/py-orange3-bioinformatics/Makefile b/biology/py-orange3-bioinformatics/Makefile
index 5464e61f4e68..2a28b9405e42 100644
--- a/biology/py-orange3-bioinformatics/Makefile
+++ b/biology/py-orange3-bioinformatics/Makefile
@@ -1,32 +1,31 @@
 PORTNAME=	orange3-bioinformatics
-DISTVERSION=	4.3.1
-PORTREVISION=	3
+DISTVERSION=	4.8.4
 CATEGORIES=	biology python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
-DISTNAME=	Orange3-Bioinformatics-${DISTVERSION}
+DISTNAME=	${PORTNAME:S/-/_/}-${DISTVERSION}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Orange add-on providing common functionality for bioinformatics
-WWW=		https://github.com/biolab/orange3-bioinformatics
+WWW=		https://github.com/biolab/orange3-bioinformatics/
 
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools-scm>0:devel/py-setuptools-scm@${PY_FLAVOR}
 RUN_DEPENDS=	orange3>0:misc/orange3 \
 		${PYTHON_PKGNAMEPREFIX}Genesis-PyAPI>0:biology/py-Genesis-PyAPI@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}point-annotator>=2.0:math/py-point-annotator@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyclipper>=1.2.0:math/py-pyclipper@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests>0:www/py-requests@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}requests-cache0>0:www/py-requests-cache0@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}resdk>0:biology/py-resdk@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}scipy>=1.5.0:science/py-scipy@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}serverfiles>0:misc/py-serverfiles@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils autoplist
+USE_PYTHON=	autoplist distutils
 
 NO_ARCH=	yes
 
 .include <bsd.port.mk>
diff --git a/biology/py-orange3-bioinformatics/distinfo b/biology/py-orange3-bioinformatics/distinfo
index 71ee4b689827..4b386c48e193 100644
--- a/biology/py-orange3-bioinformatics/distinfo
+++ b/biology/py-orange3-bioinformatics/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1619513096
-SHA256 (Orange3-Bioinformatics-4.3.1.tar.gz) = 4017518f9eeef0e8a9016a3e1c19b362f9f4d7f3e9dd07da0d8615a96a3b8447
-SIZE (Orange3-Bioinformatics-4.3.1.tar.gz) = 2943722
+TIMESTAMP = 1739870048
+SHA256 (orange3_bioinformatics-4.8.4.tar.gz) = 275a32d3948df5294350c25bb430336b5d4109afaf71edd7ccc76591cb9eeb8b
+SIZE (orange3_bioinformatics-4.8.4.tar.gz) = 3736720